环境污染物对缺氧适应的影响及机制研究进展  

Progress in research on effects of environmental pollutants on adaptation to hypoxia and their mechanisms

作　　者：赵文英 淡楠 王苏华 仇广乐[2] 冯伟伟 杨波波 肖钊 陆荣柱 ZHAO Wen-ying;DAN Nan;WANG Su-hua;QIU Guang-le;FENG Wei-wei;YANG Bo-bo;XIAO Zhao;LU Rong-zhu(Department of Preventive Medicine and Health Inspection,School of Medicine,Jiangsu University,Zhenjiang,Jiangsu Province,212013,China;State Key Laboratory of Environmental Geochemistry,Institute of Geochemistry,Chinese Academy of Sciences;Institute of Environmental Health and Ecological Security,College of Environmental and Safety Engineering,Jiangsu University)

机构地区：[1]江苏大学医学院预防医学与卫生检验系,江苏镇江212013 [2]中国科学院地球化学研究所环境地球化学国家重点实验室 [3]江苏大学环境与安全工程学院环境健康与生态安全研究院

出　　处：《环境卫生学杂志》2022年第11期834-843,共10页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：国家自然科学基金(30872139,81273124);江苏省大学生创新创业训练计划项目(202010299229Y)。

摘　　要：重金属、有机毒物等环境污染物可降低生命机体的缺氧适应能力,加重缺氧状态下的机体损伤。本文介绍了机体对缺氧的适应能力及适应机制,以及包括汞、镉、铜、镍在内的重金属污染物、常见大气污染物以及有机毒物等环境污染物对缺氧适应的不良影响及其机制,并提出未来研究应关注环境污染物对机体缺氧适应造成损伤的共同途径和机制,为环境污染物中毒及缺氧损伤的预防和临床治疗提供参考。Environmental pollutants, such as heavy metals, organic poisons, can reduce the adaptability of organisms to hypoxia, aggravating the damage to organisms under hypoxic conditions. This paper introduced organisms’ adaptability to hypoxia and the underlying mechanisms, and reviewed the harmful effects on organisms’ adaptation to hypoxia of various environmental pollutants, including heavy metals and(mercury, cadmium, copper, and nickel), common air pollutants and organic poisons, and the underlying mechanisms. Suggestion were recommended that future research should pay more attention to the common pathways and mechanisms of environmental pollutants injuring organisms’ adaptation to hypoxia, and provide a theoretical reference for the prevention and treatment of poisoning and hypoxic damage caused by environmental pollutants.

关 键 词：环境污染 缺氧适应 缺氧耐受 重金属 大气污染物 有机毒物 

分 类 号：R12[医药卫生—环境卫生学]