活血化瘀类中药在硬皮病中的应用及机制研究进展  

Progression of mechanism research and application of traditional Chinese medicine for promoting blood circulation and removing blood stasis in the treatment of scleroderma

作　　者：严悦梅 胡东艳 曹滇誉 王强 YAN Yue-mei;HU Dong-yan;CAO Dian-yu;WANG Qiang(Department of Dermatology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Dermatology,the First Hospital of Jiaxing,Jiaxing University,Jiaxing 314000,Zhejiang,China)

机构地区：[1]复旦大学附属中山医院皮肤科,上海200032 [2]嘉兴市第一医院皮肤科,嘉兴314000

出　　处：《中国临床医学》2022年第6期1034-1038,共5页Chinese Journal of Clinical Medicine

基　　金：上海市科委生物医药领域重点项目(18401931700);上海市卫健委上海市中医药管理局项目(2016ZJP001)。

摘　　要：硬皮病是一种复杂的多器官累及的自身免疫性疾病,以皮肤和内脏器官结缔组织发生进行性纤维化为特征。中医认为硬皮病属于“痹症”范畴,具有血瘀证征象,故活血化瘀治疗贯穿全程;而西医则认为,硬皮病是由血管病变、胶原合成异常、免疫紊乱等导致的结缔组织细胞外基质过度沉积。近年来,越来越多的学者发现活血化瘀类中药成功改善硬皮病动物模型的炎症、纤维化、血管病变等,并逐渐将这类中药应用于临床患者。这类动物试验结果符合西医对硬皮病发病机制的认识,也为活血化瘀类中药的应用提供了客观实验证据。Scleroderma is a complex,multiorgan,autoimmune disease that is characterized by the progressive fibrosis mainly involving the connective tissue of the skin and internal organs.Based on the traditional Chinese medicine,scleroderma belongs to the category of“Bi Zheng”with blood stasis symptom,which leads to a throughout treatment of promoting blood circulation and removing blood stasis.However,Western medicine believes that scleroderma is excessive deposition of extracellular matrix(ECM)of connective tissue caused mainly by vasculopathy,abnormal collagen synthesis and autoimmune disorder.In recent years,an increasing number of researchers have found that some of traditional Chinese herbs for promoting blood circulation and removing blood stasis can successfully improve the inflammation,fibrosis and vasculopathy in the animal models of scleroderma,and these herbs have been gradually applied to scleroderma patients.These results from animal trials accord with Western medicine’s understanding of the pathogenesis of scleroderma and provide objective experimental evidence for application of traditional Chinese herbs for promoting blood circulation and removing blood stasis in the treatment of scleroderma.

关 键 词：硬皮病 活血化瘀 中药 机制 

分 类 号：R593.25[医药卫生—内科学]