《千金方》治疗消渴用药规律数据挖掘  

Data Mining of Drug Law of Qian Jin Fang in Treating Diabetes

作　　者：呼延昕娜 呼兴华 王晓琳[2] 卢芬萍 许建秦[2] 高原 HUYAN Xinna;HU Xinghua;WANG Xiaolin;LU Fenping;XU Jianqin;GAO Yuan(Ningxia Medical University,Yinchuan 750000,China;Shaanxi Academy of Chinese Medicine,Xi'an 710003,China)

机构地区：[1]宁夏医科大学,宁夏银川750000 [2]陕西省中医药研究院,陕西西安710003

出　　处：《现代中医药》2023年第1期31-35,共5页Modern Chinese Medicine

基　　金：国家中医药管理局医史文献重点学科建设单位项目[国中医药发(2009)30号];北京中医药大学孙思邈研究院科研计划项目(SSMYJY-2-2020-13)。

摘　　要：目的整理两部《千金方》中治疗消渴的内服方剂并探索其用药规律。方法借助《中华医典》(V5)筛选《千金方》中治疗消渴的内服方剂,形成文本数据并录入中医传承辅助系统平台(V3.0)进行频数分析、关联规则等分析。结果共收集方剂80首,涉及中药143味。使用频次较高的药物为天花粉(34次,42.5%)、甘草(22次,27.5%)、茯苓(22次,27.5%)、麦冬(22次,27.5%)、黄连(17次,21.3%)、地黄(15次,18.8%)、桂枝(12次,15.00%)等,对应药性以寒(30.5%)、温(22.2%)为主,药味以甘(52.8%)、苦(31.6%)为主;药物功效频次较高的前三类药物为补虚(24.1%)、清热(17.6%)、渗湿(7.6%);关联规则分析得出13组支持度≥8的高频药对,前三位分别为天花粉→甘草、茯苓→人参、茯苓→甘草;8条置信度≥0.7的关联规则,前四位相关药物分别为“甘草,麦冬→茯苓”“生姜→甘草、天花粉”“麦冬→茯苓、天花粉”“甘草→茯苓”。结论《千金方》治疗消渴病以养阴、清热、健脾为主要方法,甘苦并用,清补结合,值得借鉴。Objective To sort out the oral prescriptions for diabetes in two Qian Jin Fang and explore the regularity of their use.Methods With the help of Zhong Hua Yi Dian(V5),we screened the internal prescriptions for diabetes in Qian Jin Fang,formed text data and entered them into the traditional Chinese medicine inheritance assistance system platform(V3.0)for frequency analysis,association rules and other analysis.Results A total of 80 prescriptions were collected,involving 143 Chinese herbs.The frequently used drugs are Trichosanthin(34 times,42.5%),Licorice(22 times,27.5%),Poria cocos(22 times,27.5%),Ophiopogon japonicus(22 times,27.5%),Coptis chinensis(17 times,21.3%),Rehmannia glutinosa(15 times,18.8%),Cinnamon twig(12 times,15.00%),etc.The corresponding drug properties are mainly cold(30.5%),warm(22.2%),and the drug flavors are mainly sweet(52.8%)and bitter(31.6%);The first three kinds of drugs with higher efficacy frequency were tonic(24.1%),heat clearing(17.6%)and moisture permeability(7.6%);Association rule analysis showed that 13 groups of high-frequency drug pairs with support≥8,the first three were respectively Trichosanthin→Licorice,Tuckahoe→Ginseng,Tuckahoe→Licorice;There are 8 association rules with confidence≥0.7.The first four related drugs are“Licorice,Ophiopogon japonicus→Tuckahoe”,“Ginger→Licorice,Trichosanthin”,“Ophiopogon japonicus→Tuckahoe,Trichosanthin”,“Licorice→Tuckahoe”.Conclusion Qian Jin Fang is mainly used to nourish Yin,clear heat and strengthen the spleen in treating diabetes,which is worth learning from.

关 键 词：消渴 千金方 寒温并用 数据挖掘 

分 类 号：R255.4[医药卫生—中医内科学]