缺血性脑卒中患者颈动脉斑块性质与非高密度脂蛋白胆固醇浓度的相关性  

Analysis of the relationship between non-high-density lipoprotein cholesterol and arterial plaque characteristic in a cohort of ischemic stroke patients

作　　者：徐建可 刘宁 韩苗 张洪阳 韩新生 Xu Jianke;Liu Ning;Han Miao;Zhang Hongyang;Han Xinsheng(Department of Neurology,Kaifeng Central Hospital,Kaifeng 475000,Henan Province,China)

机构地区：[1]开封市中心医院神经内科,河南开封475000

出　　处：《首都医科大学学报》2023年第1期49-53,共5页Journal of Capital Medical University

基　　金：河南省科技厅科技攻关计划项目(182102310445);开封市科技发展计划项目(1903036)。

摘　　要：目的探讨缺血性脑卒中老年患者不同类型的颈动脉斑块性质与血清非高密度脂蛋白胆固醇(non-high density lipoprotein-cholesterol,non-HDL-C)表达水平的关系。方法选取在开封市中心医院神经内科住院的400例动脉粥样硬化性脑梗死患者,依据颈部血管超声结果分为:稳定斑块组与不稳定斑块组。同期在本院体检中心的400例健康者设为对照组。所有入选者空腹抽取肘静脉血,使用全自动生化分析仪检测血脂和non-HDL-C。结果2组患者血清non-HDL-C浓度差异有统计学意义(P<0.05);脑梗死患者不稳定斑块组non-HDL-C浓度较稳定斑块组增高,non-HDL-C分别为(3.81±0.99)mmol/L、(2.92±0.72)mmol/L,2组比较,差异均有统计学意义(P<0.05)。经Spearman相关分析,缺血性脑卒中老年患者颈动脉斑块的不稳定性与血清non-HDL-C表达水平呈正相关(r=0.521,P<0.01)。Logistic回归分析结果表明,non-HDL-C是颈动脉不稳定斑块的重要危险因素(OR=3.990,95%CI:2.369~6.720)。结论缺血性脑卒中老年患者non-HDL-C升高发生颈动脉不稳定斑块的危险性明显增大,是颈动脉不稳定斑块的重要危险因素。Objective To investigate the relationship between non-high density lipoprotein-cholesterol(non-HDL-C)and artery plaque characterization of stroke.Methods The hospitalized patients diagnosed as atherosclerotic stroke in the neurological department of Kaifeng Central Hospital were recruited as the experimental group(400 cases),who were divided as the stable and unstable plaque groups,according to the stenosis intensity.Another 400 healthy controls were recruited.The serum levels of non-HDL-C of all the patients and control groups were detected.Results The levels of non-HDL-C were significantly different(P<0.05)between the stroke group and the health control.The levels of non-HDL-C in the unstable plaque group were significantly higher than that in the stable control group,and the mean of non-HDL-C was(3.81±0.99)mmol/L and(2.92±0.72)mmol/L,respectively,with significant difference(P<0.05).Spearman correlation ananlysis showed the levels of non-HDL-C was positively correlated with the unstable plaque(r=0.521,P<0.01).Logistic regression analysis showed that non-HDL-C was an important risk factor for carotid artery unstable plaque(OR=3.990,95%CI:2.369-6.720).Conclusion There was correlation between the non-HDL-C and arterial plaque characteristic in ischemic stroke patients,which can be used as the important basis for clinical examination.

关 键 词：非高密度脂蛋白胆固醇 斑块 颈动脉 动脉硬化 缺血性脑卒中 

分 类 号：R543[医药卫生—心血管疾病]