弥漫大B淋巴瘤血管内皮生长因子、碱性成纤维细胞生长因子、白介素-6水平与预后的关系  

Relationship between vascular endothelial growth factor, basic fibroblast growth factor, interleukin-6 levels and prognosis in diffuse large B-lymphoma

作　　者：戚永磊[1] 赵莹[1] QI Yonglei;ZHAO Ying(Department of Hematology and Lymphoma,Foshan First People's Hospital,Guangdong Province,Foshan528000,China)

机构地区：[1]广东省佛山市第一人民医院血液淋巴瘤科,广东佛山528000

出　　处：《中国当代医药》2023年第3期91-94,共4页China Modern Medicine

基　　金：广东省佛山市卫生和计生局科研课题(20190027)。

摘　　要：目的探讨弥漫大B淋巴瘤血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、白介素-6(IL-6)水平与预后的关系。方法选取2020年2月至2022年2月佛山市第一人民医院收治的100例弥漫大B淋巴瘤患者作为观察组,按照临床分期的不同分为Ⅰ~Ⅱ期(20例)和Ⅲ~Ⅳ期(80例),按照分子亚型的不同分为N-GCB(60例)、GCB型(40例)。选取同期的100例健康体检者作为对照组。经过治疗后,根据患者治疗效果分为治疗有效组、治疗无效组,对患者VEGF、bFGF、IL-6水平进行测定,分析弥漫大B淋巴瘤患者的VEGF、bFGF、IL-6水平与预后的关联性。结果观察组的IL-6、VEGF、bFGF水平高于对照组,差异有统计学意义(P<0.05);治疗前后,观察组Ⅰ~Ⅱ期患者的IL-6、VEGF、bFGF水平均低于Ⅲ~Ⅳ期,GCB患者的IL-6、VEGF、bFGF水平低于N-GCB患者,治疗有效组患者(n=80)的IL-6、VEGF、bFGF水平低于治疗无效组(n=20),差异有统计学意义(P<0.05);弥漫大B淋巴瘤患者的VEGF、bFGF、IL-6水平与预后均呈负相关(r=-0.625、-0.741、-0.779,P<0.05)。结论弥漫大B淋巴瘤VEGF、bFGF、IL-6水平能够反映患者病情,能够判断患者病理分期以及预后情况,具有一定的指导价值。Objective To investigate the relationship between the levels of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),interleukin-6(IL-6)and prognosis in diffuse large B lymphoma.Methods A total of 100 patients with diffuse large B lymphoma treated in Foshan First People's Hospital from February 2020 to February 2022 were selected as the observation group,according to different clinical stages,they were divided into stageⅠ-Ⅱ(20 cases),stageⅢ-Ⅳ(80 cases),and according to different molecular subtypes,they were divided into N-GCB type(60 cases)and GCB type(40 cases).And 100 healthy people in the same period were selected as the control group.After treatment,patients were divided into effective treatment group and ineffective treatment group according to the treatment effect.The levels of VEGF,bFGF and IL-6 in patients were measured,the correlation between VEGF,bFGF and IL-6 levels and prognosis in patients with diffuse large B lymphoma was analyzed.Results The levels of IL-6,VEGF and bFGF in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Before and after treatment,the levels of IL-6,VEGF and bFGF in stageⅠ-Ⅱof observation group were lower than those in stageⅢ-Ⅳ,the levels of IL-6,VEGF and bFGF in GCB patients were lower than those in n-GCB patients,and the levels of IL-6,VEGF and bFGF in effective treatment group(n=80)were lower than those in ineffective treatment group(n=20),the differences were statistically significant(P<0.05).VEGF,bFGF,IL-6 levels were negatively correlated with prognosis in diffuse large B lymphoma patients(r=-0.625,-0.741,-0.779,P<0.05).Conclusion The levels of VEGF,bFGF and IL-6 in diffuse large B-lymphoma can reflect the patients'condition,judge the patients'pathological stage and prognosis,and have certain guiding value.

关 键 词：弥漫大B淋巴瘤 血管内皮生长因子 碱性成纤维细胞生长因子 白介素-6 预后 

分 类 号：R711.2[医药卫生—妇产科学]