线粒体NAD水平在心房颤动炎性反应中的研究进展  

Advances in research on mitochondrial NAD levels in atrial fibrillation inflammatory response

作　　者：陈杰 康品方[1] 刘进军[1] Chen Jie;Kang Pinfang;Liu Jinjun(Department of cardiovascular medicine,the first affiliated hospital of Bengbu Medical College,Bengbu,Anhui,233000,China)

机构地区：[1]蚌埠医学院第一附属医院心血管内科,安徽蚌埠233000

出　　处：《齐齐哈尔医学院学报》2022年第24期2339-2343,共5页Journal of Qiqihar Medical University

基　　金：安徽省自然科学基金项目(1908085QH353);蚌埠医学院512人才培育计划(by51201315);安徽省教育厅重大项目(KJ2021ZD0082)。

摘　　要：烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD)具有心脏保护和潜在的抗炎作用,但对于治疗心房颤动中炎症反应的研究未见报道,目前已有研究者通过检测房颤和炎症细胞因子(NLRP3炎症体/caspase I轴以及活性IL-1β和IL-18等)的表达,探讨炎症细胞因子中线粒体功能障碍和炎症激活之间的机制联系。本综述旨在叙述心房颤动发生过程中相关炎症因子的影响机理,且说明线粒体NAD起到的调节作用。Nicotinamide adenine dinucleotide(NAD)has heart protection and potential anti-inflammatory effects.However,there is no report on the inflammatory response in the treatment of atrial fibrillation.There are currently researchers explore the mechanism between mitochondrial dysfunction in inflammatory cells and inflammation activation,through detecting atrial fibrillation and inflammatory cytokines expression(NLRP3 inflammatory/caspase I axes and active IL-1βand IL-18,etc.).This review is intended to describe the role of the related inflammatory factors and the role of mitochondrial NAD in the process of the atrial fibrillation.

关 键 词：烟酰胺腺嘌呤二核苷酸 心房颤动 炎症因子 

分 类 号：R541.75[医药卫生—心血管疾病]