血液灌流联合血液透析对尿毒症患者肾功能及血清Hcy、AGEs水平的影响  

Effects of Hemoperfusion Combined with Hemodialysis on Renal function and Serum Hcy and AGEs Levels in Uremic Patients

作　　者：方庆柏 田霞 张伟 FANG Qingbai;TIAN Xia;ZHANG Wei(Zhongwu Hospital,Suqian City,Suqian 223800,China;不详)

机构地区：[1]宿迁市钟吾医院,江苏宿迁223800

出　　处：《中外医学研究》2022年第36期20-23,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：宿迁市指导性科技计划项目(Z2020099)。

摘　　要：目的:探究血液灌流联合血液透析对尿毒症患者肾功能及血清同型半胱氨酸(Hcy)、晚期糖基化终末产物(AGEs)水平的影响。方法:选取2018年6月-2021年12月宿迁市钟吾医院收治的122例尿毒症患者,根据随机数字表法将其分为研究组61例,常规组61例,常规组进行血液透析,研究组则血液灌流联合血液透析治疗。治疗前1 d、治疗24周后采集患者空腹肘静脉血4 ml,检测患者尿素氮(BUN)和血肌酐(Scr)含量水平;采用全自动免疫分析仪对患者Hcy及AGEs水平进行检测。记录患者透析期间及透析后出现的不良反应,包括恶心呕吐、高血压、头晕头痛等。结果:治疗前,两组BUN、Scr水平比较差异无统计学意义(P>0.05),治疗后,两组BUN、Scr水平均降低,且研究组BUN、Scr水平低于常规组(P<0.05)。治疗前,两组Hcy、AGEs水平比较差异无统计学意义(P>0.05),治疗后,两组Hcy水平降低,且研究组Hcy水平低于常规组(P<0.05);研究组AGEs水平降低,且研究组AGEs水平低于常规组(P<0.05)。研究组治疗期间及治疗后出现恶心呕吐、腹泻及头晕头痛各1例,不良反应发生率为4.92%,常规组出现恶心呕吐、头晕头痛各2例,高血压及腹泻各1例,不良反应发生率为9.84%,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:血液灌流联合血液透析能够改善尿毒症患者肾功能,有效降低Hcy、AGEs水平,未增加不良反应的发生,值得推广并应用。Objective:To investigate the effects of hemoperfusion combined with hemodialysis on renal function,serum homocysteine(Hcy)and advanced glycation end products(AGEs)in uremic patients.Method:A total of 122 uremic patients admitted to Zhongwu Hospital,Suqian City from June 2018 to December 2021 were selected and divided into two groups according to the random number table method.There were 61 patients in the study group,61 patients in the routine group,the routine group was treated with hemodialysis,and the study group were treated with hemoperfusion combined with hemodialysis.Four ml of fasting elbow venous blood was collected from the patients 1 d before treatment and 24 weeks after treatment to detect the content of urea nitrogen(BUN)and serum creatinine(Scr).The levels of Hcy and AGEs were detected by automatic immunoanalyzer.Adverse reactions during and after dialysis,including nausea,vomiting,hypertension,dizziness and headache were recorded.Result:Before treatment,there were no significant differences in the levels of BUN and Scr between the two groups(P>0.05).After treatment,the levels of BUN and Scr in the two groups decreased,and the levels of BUN and Scr in the study group were lower than those in the routine group(P<0.05).There were no significant differences in Hcy and AGEs levels between the two groups before treatment(P>0.05).After treatment,Hcy levels in the two groups were decreased,and Hcy level in the study group was lower than that in the routine group(P<0.05);the level of AGEs in the study group was decreased,the level of AGEs in the study group was lower than that in the routine group(P<0.05).During and after treatment,there was 1 case of nausea,vomiting,diarrhea,dizziness and headache in the study group,and the incidence of adverse reactions was 4.92%;in the routine group,there were 2 cases of nausea,dizziness and headache,and 1 case of hypertension and diarrhea,and the incidence of adverse reactions was 9.84%,there was no significant difference in the incidence of adverse reactions between th

关 键 词：血液灌流 血液透析 尿毒症患者 肾功能 血清同型半胱氨酸 晚期糖基化终末产物 不良反应 

分 类 号：R692.5[医药卫生—泌尿科学]