益生菌联合多潘立酮治疗功能性消化不良患儿的效果及对胃动力学和脑肠轴相关因子的影响  

Efficacy of Probiotics Combined with Domperidone in the Treatment of Children with Functional Dyspepsia and Its Influence on Gastric Dynamics and Brain-gut Axis-related Factors

作　　者：许凯丽 徐初石 谢宝忠 赖富煌 XU Kaili;XU Chushi;XIE Baozhong;LAI Fuhuang(The First Hospital of Longyan City,Longyan 364000,China;不详)

机构地区：[1]龙岩市第一医院,福建龙岩364000

出　　处：《中外医学研究》2022年第36期42-46,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨益生菌联合多潘立酮治疗功能性消化不良(FD)患儿的效果及对胃动力学和脑肠轴相关因子的影响。方法:纳入2020年6月-2022年1月龙岩市第一医院收治的200例FD患儿作为观察对象,按随机数字表法将其分为对照组和观察组,各100例。所有患儿均给予常规支持治疗,对照组给予多潘立酮,观察组在对照组基础上增加益生菌治疗。对比两组治疗效果、脑肠轴相关因子、胃肠激素水平、胃动力学。结果:观察组治疗7 d后总有效率高于对照组(91.00%>81.00%,P<0.05)。治疗7 d后,两组5-羟色胺(5-HT)、P物质(SP)、胃动素(MTL)、血清神经肽Y(NPY)水平均高于治疗前,神经肽S受体1(NPSR1)、血管活性肠肽(VIP)水平均低于治疗前,且观察组均优于对照组(P<0.05)。治疗7 d后,两组胃窦收缩幅度、胃窦收缩频率均大于治疗前,胃半排空时间均短于治疗前,且观察组均优于对照组(P<0.05)。结论:益生菌联合多潘立酮可调节FD患儿的胃肠激素水平的释放和脑肠轴功能,改善胃动力学,从而提高治疗效果。Objective:To investigate the effect of Probiotics combined with Domperidone in the treatment of children with functional dyspepsia(FD)and its influence on gastric dynamics and brain-gut axis-related factors.Method:A total of 200 children with FD who admitted to the First Hospital of Longyan City from June 2020 to January 2022 were included as the observation objects,and they were divided into the control group and the observation group according to the random number table method,100 cases in each group.All children were given routine supportive treatment,the control group was given Domperidone,and the observation group was given Probiotic treatment on the basis of the control group.The therapeutic effects,brain-gut axis-related factors,gastrointestinal hormone levels and gastric dynamics were compared between two groups.Result:The total effective rate of the observation group after 7 d of treatment was higher than that of the control group(91.00%>81.00%,P<0.05).After 7 d of treatment,the levels of 5-hydroxytryptamine(5-HT),substance P(SP),motilin(MTL),serum neuropeptide Y(NPY)in two groups were higher than those before treatment,neuropeptide S receptor 1(NPSR1),vasoactive intestinal peptide(VIP)in two groups were lower than those before treatment,and the observation group were better than those in the control group(P<0.05).After 7 d of treatment,the contraction amplitude and frequency of gastric antrum in two groups were greater than those before treatment,and the gastric half-emptying time was shorter than that before treatment,the observation group were better than those in the control group(P<0.05).Conclusion:Probiotics combined with Domperidone can regulate the release of gastrointestinal hormone levels and brain-gut axis function in children with FD,and improve the gastric dynamics,thereby improve the therapeutic effect.

关 键 词：益生菌 多潘立酮 功能性消化不良 胃动力学 

分 类 号：R725.7[医药卫生—儿科]