血清25-羟基维生素D水平与新生儿感染性肺炎风险的相关性  

Correlation of Serum 25-Hydroxy-Vitamin D Level with the Risk of Infectious Pneumonia in Newborns

作　　者：赵晓芬[1] 杨米凤 赵朋娜 熊飞 和灿琳[1] 郝婷婷 ZHAO Xiaofen;YANG Mifeng;ZHAO Pengna;XIONG Fei;HE Canlin;HAO Tingting(Department of Neonatology,Kunming Children’s Hospital,Yunan Kunming 650228,China)

机构地区：[1]昆明市儿童医院新生儿科,云南昆明650228

出　　处：《中国医药导刊》2022年第12期1190-1193,共4页Chinese Journal of Medicinal Guide

基　　金：昆明市卫生健康委员会卫生科研课题项目(项目编号:2020-06-03-001,项目名称:IL-6与IL-10基因多态性与新生儿败血症的相关性研究)。

摘　　要：目的:探讨新生儿及其母亲血清25-羟基维生素D[25-(OH)D]水平与新生儿感染性肺炎风险之间的相关性。方法:选取2020年1月至12月在我院住院治疗的新生儿感染性肺炎患儿80例,设为病例组;对照组为80例同期住院、无感染指征的新生儿。比较两组患儿及其母亲的血清25-(OH)D水平,并对两组患儿的血白细胞(WBC)、超敏C反应蛋白(CRP)、降钙素原(PCT)水平进行比较;对病例组患儿血清25-(OH)D水平与WBC、CRP及PCT水平的相关性分析采用Spearman秩相关分析。结果:病例组患儿及其母亲的血清25-(OH)D水平分别为(45.30±16.35)、(53.07±17.49) nmol·L^(-1);对照组新生儿及其母亲的血清25-(OH)D水平分别为(57.94±16.94)、(61.49±19.50) nmol·L^(-1);病例组患儿及其母亲的血清25-(OH)D水平均低于对照组患儿及其母亲(P<0.05)。病例组患儿血清CRP、PCT水平均高于对照组(P<0.05);病例组患儿的血清CRP、PCT水平与血清25-(OH)D水平呈负相关(P<0.05);WBC水平与血清25-(OH)D水平无相关性(P>0.05)。结论:病例组患儿及其母亲的血清25-(OH)D水平较对照组低,提示血清25-(OH)D水平降低可增加新生儿患感染性肺炎的风险。推荐母孕期及新生儿补充足量维生素D,以助于提高新生儿的呼吸道健康水平。Objective:To explore the correlation of serum 25-hydroxy-vitamin D [25-(OH)D] levels of newborns and their mothers with the risk of infectious pneumonia in newborns. Methods: 80 cases of neonatal infective pneumonia who hospitalized in our hospital from January to December 2020 were selected as the case group, and 80 newborns hospitalized in our hospital during the same period without infective symptom were selected as the control group. The levels of serum 25-(OH)D of the two groups of newborns and their mothers were compared. The levels of WBC, CRP and PCT were compared between the two groups of newborns. Spearman rank correlation analysis was performed to investigate the correlation of serum 25-(OH)D level with WBC, PCT and CRP levels in the case group. Results: The serum 25-(OH)D levels of newborns and their mothers in the case group were(45.30±16.35) and(53.07±17.49) nmol·L^(-1)respectively.The serum 25-(OH)D levels of newborns and their mothers in the control group were(57.94±16.94) and(61.49±19.50) nmol·L^(-1)respectively.The serum 25-(OH)D levels of newborns and their mothers in the case group were lower than those of the control group(P<0.05). The serum CRP and PCT levels of newborns in the case group were higher than those of the control group(P<0.05). The serum CRP and PCT levels of newborns in the case group were negatively correlated with serum 25-(OH)D level(P<0.05), and there was no correlation between WBC level and serum 25-(OH)D level of the newborns in the case group(P>0.05). Conclusion: The serum 25-(OH)D levels of newborns and their mothers in the case group were lower than those of the control group, which indicated that the lower level of serum 25-(OH)D might be associated with increased risk of infectious pneumonia in newborns. The appropriate supplement of vitamin D druing pregnancy and the neonatal period is recommended to help improve the respiratory health of newborns.

关 键 词：25-羟基维生素D 感染性肺炎 新生儿 

分 类 号：R722.1[医药卫生—儿科]