5-氨基酮戊酸光动力疗法治疗尖锐湿疣的免疫机制研究进展  

Research progress on the immune mechanism of 5-aminolevulinic acid photodynamic therapy for condyloma acuminatum

作　　者：钟依秀 张志文 肖紫璇 鹿洪艳 戴丝淇 曾抗[1] ZHONG Yi-xiu;ZHANG Zhi-wen;XIAO Zi-xuan(Department of Dermatology,Nanfang Hospital,the Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院皮肤科,广州510515

出　　处：《实用皮肤病学杂志》2022年第5期283-286,共4页Journal of Practical Dermatology

基　　金：国家自然科学基金面上项目(82073464)。

摘　　要：尖锐湿疣(CA)是一种由人乳头瘤病毒(HPV)感染引起的常见的性传播疾病。5-氨基酮戊酸光动力疗法(5-ALA-PDT)是近年来治疗CA的一种安全有效的疗法。目前认为PDT能够诱导机体免疫应答,但是其具体机制不明。该文就5-ALA-PDT治疗CA的免疫机制相关研究进展作一综述,以期为日后研究相关机制及其临床应用提供参考。Condylomaacuminata(CA)is a common sexually transmitted disease caused by human papillomavirus(HPV)infection.In recent years,5-aminolaevulinic acid photodynamic therapy(5-ALA-PDT)emerges as a safe and effective treatment for CA.Currently,it is believed that PDT can induce an immune response.However,its underlying mechanism is unknown.This article summarizes the research progress of the immune mechanism of 5-ALA-PDT in the treatment of CA,to provide a reference for future research on mechanisms and clinical applications.

关 键 词：尖锐湿疣 光动力疗法 5-氨基酮戊酸 人乳头瘤病毒 固有免疫 适应性免疫 

分 类 号：R752.53[医药卫生—皮肤病学与性病学] R751.05[医药卫生—临床医学]