ROX指数预测老年重症社区获得性肺炎患者气管插管的有效性分析  

Analysis of the effectiveness of ROX index in predicting tracheal intubation in elderly patients with severe community-acquired pneumonia

作　　者：王重阳 王璐[1] 郭仁楠 沙丽恒·阿布德克 肖东[1] WANG Chongyang;WANG Lu;GUO Rennan;SHALIHEN·Abudeke;XIAO Dong(Department of Intensive Care Medicine,Xinjiang Uygur Autonomous Region People's Hospital,Urumqi,830001,China)

机构地区：[1]新疆维吾尔自治区人民医院重症医学科,乌鲁木齐830001

出　　处：《临床急诊杂志》2022年第12期854-858,共5页Journal of Clinical Emergency

摘　　要：目的:探讨ROX指数预测老年重症社区获得性肺炎(SCAP)患者气管插管的有效性。方法:选取既往于2022年1月1日—2022年9月1日新疆维吾尔自治区人民医院EICU收治的71例老年SCAP患者作为研究对象,根据患者住院期间是否进行气管插管,将其分为未插管组46例和插管组25例。比较2组一般资料:年龄、性别、体重指数(BMI)、基础疾病构成比、入院时APACHEⅡ评分、SOFA评分、CURB-65评分、白细胞计数、血小板计数、C反应蛋白(CRP)、降钙素原(PCT)、动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)、平均动脉压(MAP)、入院30 min内最差ROX指数、插管前30 min内最差ROX指数;并采用多因素logistic回归分析气管插管的独立显著预测因子;采用受试者工作曲线(ROC)确定最佳的气管插管预测截断值。结果:共计纳入研究的患者71例(男45例,女26例),非插管组46例(中位数年龄76岁),插管组25例(中位数年龄75岁);2组患者的年龄、性别、BMI、CURB-65评分、既往基础疾病构成比、入院时白细胞计数、血小板计数、CRP、MAP对比差异无统计学意义(均P>0.05);2组患者入院时的APACHEⅡ评分(t=-2.925,P=0.005)、SOFA评分(t=-2.411,P=0.019)、合并3种以上基础疾病构成比(χ^(2)=-4.610,P=0.032)、PCT(t=-2.238,P=0.028)、PaO2(t=2.688,P=0.009)、PaO2/FiO2(t=2.881,P=0.005)、入院30 min内最差ROX指数(t=5.816,P<0.001)、插管前30 min内最差ROX指数(t=7.930,P<0.001)对比,差异有统计学意义(均P<0.05)。多因素二元logistic回归分析显示,插管前30 min内最差ROX指数为是否插管的独立影响因素(OR=0.06,P=0.02)。插管前30 min内最差ROX指数对气管插管预测的ROC曲线下面积为0.93(95%CI:0.01~0.60,P<0.001)。最大约登指数为0.67,最佳截断值ROX指数=5.5时,对气管插管预测的灵敏度为0.67,特异度为0.97。结论:插管前ROX指数对预测老年SCAP患者气管插管的准确性较高,动态监测ROX指数有助于临床医师把握老年SCAP患�Objective: To investigate the effectiveness of ROX index in predicting tracheal intubation in elderly patients with Serious community acquired pneumonia(SCAP). Methods: Seventy-one elderly SCAP patients previously admitted to the EICU of the People’s Hospital of Xinjiang Uygur Autonomous Region from January 1, 2022 to September 1, 2022 were selected as study subjects and were divided into non-intubated group(46 cases) and intubated group(25 cases) according to whether the patients were intubated or not during hospitalization. The general data of the two groups were compared: age, gender, BMI, basic disease constituent ratio, APACHE Ⅱ score at admission, SOFA score, CURB-65 score, white blood cell count, platelet count, CRP, PCT, PaO2, PaO2/FiO2, MAP, worst ROX index within 30 min of admission, and worst ROX index within 30 min before intubation;and independent significant predictors of tracheal intubation were analyzed using multifactorial logistic regression;the subject operating curve(ROC) was used to determine the best predictive cutoff value for tracheal intubation. Results: A total of 71 patients(45 males and 26 females) were included in the study, 46 in the non-intubated group(median age 76 years) and 25 in the intubated group(median age 75 years);there were no significant differences in age, gender, BMI, CURB-65 score, previous basic disease constituent ratio, white blood cell count at admission, platelet count, CRP, and MAP between the two groups(all P>0.05);the APACHE Ⅱ score(t=-2.925, P=0.005), SOFA score(t=-2.411, P=0.019), combined three or more basic disease constituent ratio(χ^(2)=-4.610, P=0.032), PCT(t=-2.238, P=0.028), PaO2(t=2.688, P=0.009), PaO2/FiO2(t=2.881, P=0.005), worst ROX index within 30 min of admission(t=5.816, P<0.001), and worst ROX index within 30 min before intubation(t=7.930, P<0.001) were significantly different in comparison(all P<0.05). Multi-factor binary logistic regression analysis showed that the worst ROX index within 30 min before intubation was an independent fact

关 键 词：重症社区获得性肺炎 ROX指数 气管插管 预测 

分 类 号：R563.1[医药卫生—呼吸系统]