A型肉毒毒素治疗慢性鼻炎的研究进展  

Research progress of botulinum toxin type A in the treatment of chronic rhinitis

作　　者：张元文[1] 王桂芳[2] ZHANG Yuanwen;WANG Guifang(Department of Burns and Plastic Surgery,No.926 Hospital,Joint Logistics Support Force of PLA,Kaiyuan,661600,China;Department of Otolaryngology Head and Neck Surgery,No.926 Hospital,Joint Logistics Support Force of PLA,Kaiyuan,661600,China)

机构地区：[1]中国人民解放军联勤保障部队第926医院烧伤整形科,云南开远661600 [2]中国人民解放军联勤保障部队第926医院耳鼻咽喉头颈外科,云南开远661600

出　　处：《临床耳鼻咽喉头颈外科杂志》2022年第11期878-883,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：肉毒毒素是由肉毒梭菌产生的神经毒素超家族,通过抑制突触前神经末梢神经递质的释放,干扰神经肌肉和神经腺体接头处的信号传递,已广泛用于神经肌肉、腺体分泌过多和自主神经系统疾病。近年来,A型肉毒毒素被用于治疗慢性鼻炎。研究表明A型肉毒毒素鼻腔给药安全有效,可以减轻患者的鼻部症状,并且效果持久。本文对A型肉毒毒素治疗慢性鼻炎的研究进展进行综述。Botulinum toxin(BoNT),a superfamily of neurotoxins produced by the bacterium Clostridium botulinum,disturbs the signal transmission at the neuromuscular and neuroglandular junctions by inhibiting the neurotransmitter release from the presynaptic nerve terminal.BoNT has been widely used in neuromuscular,hypersecretory,and autonomic nerve system disorders.In recent years,botulinum toxin type A(BoNT-A)has been used to treat chronic rhinitis.Studies have shown that intranasal administration of BoNT-A is safe and effective,and can reduce nasal symptoms in rhinitis patients with long-lasting effects.This article reviews the research progress of BoNT-A in the treatment of chronic rhinitis.

关 键 词：鼻炎 肉毒毒素 鼻腔给药 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]