角蛋白生物医学应用研究进展  

Research Progress of Keratin in Biomedical Applications

作　　者：王丽娟 杜劲松 胡海萍 韩晓 商钰爽 袁江[1] 沈健[1] WANG Li-juan;DU Jin-song;HU Hai-ping;HAN Xiao;SHANG Yu-shuang;YUAN Jiang;SHEN Jian(Jiangsu Key Laboratory of Biofunctional Materials,College of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China)

机构地区：[1]江苏省生物功能材料重点实验室,南京师范大学化学与材料科学学院,南京210023

出　　处：《高分子通报》2023年第1期41-53,共13页Polymer Bulletin

基　　金：生物医药功能材料国家地方联合创新服务平台建设(2014103SB90102);江苏省教育厅基金(19KJA310001)。

摘　　要：角蛋白是一种结构稳定,生物相容性良好的可再生资源,由于其良好的生物相容性、自然丰度和独特的分子结构而被广泛应用于生物医学领域。本文首先介绍了角蛋白的结构特点和提取方法,重点阐述人发角蛋白材料在药物缓释、伤口修复、组织工程等领域的应用。最后,对角蛋白生物材料的未来发展趋势进行了展望。Keratin is a kind of renewable resources with stable structure and great biocompatibility, which has been widely used in biomedical field due to its good biocompatibility, natural abundance, and unique molecular structure. In this review, the structure property and extraction of keratin are introduced. Especially, the biomedical applications of keratin materials in the fields of drug release, wound repair, and tissue engineering are emphasized. Finally, the future development trend is forecasted.

关 键 词：角蛋白 伤口修复 药物缓释 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]