Genome-wide DNA methylation profiling reveals candidate biomarkers and probable molecular mechanism of metabolic syndrome  

作　　者：Su-Jin Baek Hyo-Jeong Ban Sang-Min Park Soo Yeon Kim Siwoo Lee Hee-Jeong Jin 

机构地区：[1]KM Data Division,Korea Institute of Oriental Medicine,1672 Yuseong-daero,Yuseong-gu,Daejeon 34054,Republic of Korea

出　　处：《Genes & Diseases》2022年第4期833-836,共4页基因与疾病（英文）

基　　金：This study was supported by the“Development of Korean Medicine Original Technology for Preventive Treatment based on Integrative Big Data”grant from the Korea Institute of Oriental Medicine(No.KSN2023120).

摘　　要：Although aberrant DNA methylation changes are significantly associated with the pathogenesis of many diseases,little is known about the molecular mechanisms underlying interactions between DNA methylation and gene expression in metabolic syndrome(MetS).The aim of this study was to identify biomarkers and molecular mechanisms regulated by DNA methylation in MetS.We profiled genome-wide DNA methylation using the Infinium MethylationEPIC BeadChIP and characterized the transcriptome by RNA sequencing in our study population comprised of subjects with MetS(n=11)and controls(n=9).

关 键 词：diseases pathogenesis EPIC 

分 类 号：R589[医药卫生—内分泌]