MAGI3在脑胶质瘤中对PTEN和PI3K/AKT通路的影响  

MAGI3 Positively Regulates Anti-Oncogene PTEN in Glioma

作　　者：陈冰 王毅[1] 赵余静 苗俊杰 魏广鑫[1] 王喆[1] 胡良昌 解昆明 Chen Bing;Wang Yi;Zhao Yujing;Miao Yunjie;Wei Gaungxin;Wang Zhe;Hu Liangchang;Xie Kunming(Fifth Department of Neurosurgey,Weifang Peoples Hospital,Weifang 261000,China;The First Affiliated Clinical Medical College of Weifang Medical College,Weifang 261000,China)

机构地区：[1]潍坊市人民医院神经外五科,山东潍坊261000 [2]潍坊医学院附属第一临床医学院,山东潍坊261000

出　　处：《南开大学学报（自然科学版）》2022年第5期106-111,共6页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：潍坊医学院博士启动基金(041005)。

摘　　要：胶质瘤是原发于颅脑的恶性肿瘤,治疗效果差,生存期短,抑癌基因PTEN是继P53之后发现的在胶质瘤发生发展中占第二位的抑癌基因.探讨含有PDZ结构域的MAGI3在脑胶质瘤中表达情况及其对抑癌基因PTEN表达的影响,为临床脑胶质瘤的治疗提供新的思路.结果显示MAGI3-C6组及人脑胶质瘤组PTEN水平明显升高,P-AKT/AKT水平明显降低.从而得出在胶质瘤中,MAGI3可以正性调控抑癌基因PTEN蛋白表达.MAGI3可以通过提高PTEN表达抑制AKT磷酸化从而抑制肿瘤细胞的生长.Glioma is a malignant tumor originating in the brain,with poor therapeutic effect and short survival period.Tumor suppressor gene PTEN is the second tumor suppressor gene discovered after P53 in the occurrence and development of glioma.The expression of MAGI3 with PDZ domain in glioma and its effect on the expression of tumor suppressor gene PTEN were investigated,providing new ideas for the treatment of clinical glioma.The results showed that the level of PTEN in MAGI3-C6 group and human glioma group was significantly increased,and the level of P-Akt/AKT was significantly decreased.Thus,The research concluded that MAGI3 positively regulates the expression of tumor suppressor gene PTEN protein in glioma.MAGI3 can inhibit tumor cell growth by increasing PTEN expression and inhibiting AKT phosphorylation.

关 键 词：胶质瘤 MAGI3 PTEN PI3K/AKT 

分 类 号：Q812[生物学—生物工程]