运动负荷超声心动图联合斑点追踪成像评估肥厚型心肌病患者右心功能的研究  

Evaluation of right ventricular function in patients with hypertrophic cardiomyopathy by exercise stress echocardiography combined with speckle tracking imaging

作　　者：杨帆 王静 康楠 王博 焦杨 王楚钧 拓胜军 刘丽文 YANG Fan;WANG Jing;KANG Nan;WANG Bo;JIAO Yang;WANG Chujun;TA Shengjun;LIU Liwen(Department of Ultrasound,Xijing Hospital,The First Affiliated Hospital of Air Force Medical University of PLA,Xi'an,710032,China)

机构地区：[1]中国人民解放军空军军医大学第一附属医院、西京医院超声医学科,西安710032

出　　处：《临床心血管病杂志》2022年第12期934-940,共7页Journal of Clinical Cardiology

基　　金：国家自然科学基金(No:82230065、82071932、82272009);军队装备重点课题(No:KJ20191A05XXXX);陕西省重点研发计划国际科技合作计划项目(No:2022KW-32);西京医院学科助推计划(No:XJZT18Z03);空军军医大学临床研究资助计划实施方案(No:2021XD010);空军军医大学凌云计划人才扶持计划(No:2020lyjhllw);西京医院科技发展基金(No:YYKJFZJJ2018Y002)。

摘　　要：目的采用运动负荷超声心动图联合二维斑点追踪成像(two-dimensional speckle tracking imaging,2D-STI)技术评估肥厚型心肌病(hypertrophic cardiomyopathy,HCM)患者右心功能及运动储备能力,并探讨右心室肥厚(right ventricular hypertrophy,RVH)对患者临床表现及运动能力的影响。方法连续纳入2020年4月—2020年9月西京医院HCM诊疗中心就诊的HCM患者60例,根据右心室室壁厚度分为HCM不伴RVH组25例,HCM伴RVH组35例,再纳入HCM患者的健康家属29例为对照组,对所有入选研究对象行常规及运动负荷超声心动图检查。通过运动负荷超声心动图,测量并分析受试者在休息和运动条件下的右心室功能参数和应变值。三维图像测量静息状态三维右室舒张末期容积(RV_3D_EDV)、三维右室收缩末期容积(RV_3D_ESV)、右心室射血分数(RV_3D_EF);二维图像测量其静息和运动状态下右心室面积变化分数(RVFAC)、三尖瓣环收缩期位移(TAPSE)等常规心脏超声参数,并联合二维斑点追踪成像测量右心室游离壁基底部、中间部、心尖部纵向应变(RV_LS_BAS、RV_LS_MID、RV_LS_API)、右心室游离壁整体纵向应变(RV_GLS)及储备能力。结果①静息期,HCM伴RVH组患者NYHAⅢ/Ⅳ及胸痛、胸闷、服药史(血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体拮抗剂、β受体阻滞剂、钙离子拮抗剂)等临床表现出现比例最大(P<0.05);且此组患者RVFAC、RV_3D_EF、右心室游离壁各节段及整体应变值(RV_LS_BAS、RV_LS_MID、RV_LS_API、RV_GLS)均为最小(P<0.05);HCM不伴RVH组患者右心室收缩功能参数及应变值与对照组无统计学差异。②运动激发后,HCM组患者右心室游离壁各节段应变、整体应变及储备能力均明显低于对照组,且HCM伴RVH组患者运动时长及代谢当量(METs)为3组中最差(P<0.05)。结论HCM伴RVH患者临床症状明显较重,静息期出现右心室功能受累,运动激发后右心室收缩功能、储备能力、运�Objective: To evaluate the right ventricular function and exercise reserve in patients with hypertrophic cardiomyopathy(HCM) by using exercise stress echocardiography combined with two-dimensional speckle tracking imaging(2 D-STI), and to explore the effect of right ventricular hypertrophy(RVH) on the clinical manifestations and exercise capacity of patients. Methods: Sixty patients with HCM who were admitted to theXijing Hypertrophic Cardiomyopathy Center from April 2020 to September 2020 were included. They were divided two groups depending on the thickness of the right ventricular-one with 25 HCM patients without RVH and another with 35 that did have RVH. In addition, 29 healthy family members of HCM patients were included as the control group. Routine and exercise stress echocardiography was performed on all selected subjects. Through exercise stress echocardiography, the right ventricular functional parameters and strain values of the selected subjects under resting and exercise conditions were measured and analyzed. Three dimensional echocardiography was used to measure three dimensional right ventricular end diastolic volume(RV_3 D_EDV), three dimensional right ventricular end systolic volume(RV_3 D_ESV), and right ventricular ejection fraction(RV_3 D_EF) at rest. The conventional cardiac parameters such as right ventricular factional area change(RVFAC) and tricuspid annular systolic displacement(TAPSE) were measured with two-dimensional image.The longitudinal strains at the base, middle, apex, global of the right ventricle free wall(RV_LS_BAS, RV_LS_MID, RV_LS_API, RV_GLS) and reserve capacity were measured with two-dimensional speckle tracking imaging under resting and exercise conditions. Results:(1)In the resting period, the HCM with RVHgroup had a greatest proportion of NYHA Ⅲ/Ⅳ, chest pain, chest tightness, and medication history among the three groups(P<0.05). The absolute values of right ventricular factional area change(RVFAC), three-dimensional right ventricular ejection fraction(RV_3 D_EF),

关 键 词：肥厚型心肌病 右心室肥厚 二维斑点追踪成像 运动负荷超声心动图 

分 类 号：R542.2[医药卫生—心血管疾病]