心脏原位巨噬细胞在心肌梗死及缺血再灌注损伤治疗中的作用  

The role of cardiac resident macrophages in myocardial infarction and ischemia-reperfusion injury

作　　者：集铄媛 刘德敏[1] 谷国强[1] JI Shuoyuan;LIU Demin;GU Guoqiang(Department of Cardiology,the Second Hospital of Hebei Medical University,Shijiazhuang,050000,China)

机构地区：[1]河北医科大学第二医院心内一科,石家庄050000

出　　处：《临床心血管病杂志》2022年第12期1001-1006,共6页Journal of Clinical Cardiology

基　　金：河北省自然科学基金(No:H2021206220);河北省自然科学基金(No:H2020206409)。

摘　　要：传统观点认为,组织巨噬细胞由循环系统中骨髓来源的单核细胞分化产生,近期研究通过单细胞测序、遗传谱系示踪(genetic fate mapping and lineage tracing)等技术探究心脏巨噬细胞的分群及起源,发现心脏中的部分巨噬细胞在胚胎期即进入心脏,由卵黄囊中的前体细胞、胎肝单核细胞分化形成,并通过原位增殖维持细胞数目,该类细胞被称为心脏原位巨噬细胞。心脏原位巨噬细胞在稳态和损伤后心脏中发挥免疫作用,参与心肌缺血及恢复血流后的再灌注损伤过程中的炎症反应。本文结合最新研究进展,介绍了心脏原位巨噬细胞的来源及分型,并主要就心脏原位巨噬细胞在心肌梗死及血管再通导致的缺血再灌注损伤中发挥的作用作一综述,旨在为改善心肌梗死的临床预后提供新的思路。The long-held notion was that tissue macrophages replenish from circulation monocytes.However,evidence has established that the majority of macrophages are established prenatally,originating from yolk sac progenitors and fetal liver monocytes,and maintained via in situ proliferation by using genetic fate mapping and lineage tracing techniques to investigate the origin of the cardiac macrophages.For their embryonic origin and self-renewal capacity,this population is defined as cardiac resident macrophage(CRM).CRMs are involved in the immune response in steady and following the disruption of homeostasis,including their specific role and contribution in the process of myocardial infarction and ischemia-reperfusion injury.According to the latest research progress,this review introduces the origin and classification of CRM.We describe their crucial roles in response to inflammation during cardiac ischemic injury,to provide new ideas for improving the clinical prognosis of myocardial infarction.

关 键 词：心脏原位巨噬细胞 心肌梗死 心肌缺血再灌注损伤 

分 类 号：R542.2[医药卫生—心血管疾病]