2岁以下儿童肝移植应用伏立康唑的药学监护  

Analysis of Pharmaceutical Care on the Use of Voriconazole in Pediatric Liver Transplantation Patients Younger Than 2 Years of Age

作　　者：王维娜[1] 程晟[1] 卫红涛[1] 沈素[1] Wang Weina;Cheng Sheng;Wei Hongtao;Shen Su(Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院,北京100050

出　　处：《儿科药学杂志》2023年第1期11-14,共4页Journal of Pediatric Pharmacy

摘　　要：目的:通过对2岁以下肝移植受者伏立康唑的应用现状进行回顾性分析,为临床药师深入开展药学监护提供有效的切入点和工作思路。方法:对2017-2019年某院2岁以下肝移植患儿应用伏立康唑的情况进行调查和分析。结果:126例患儿使用伏立康唑预防或治疗侵袭性真菌病,初始剂量为4~6 mg/kg,每日2次,不良反应发生率为0.79%。96例治疗性用药患儿的总有效率为96.8%,30例预防性用药患儿的预防成功率为86.67%。结论:临床药师可以根据循证证据从初始用药剂量、血药浓度监测、用药剂量调整、重点指标的综合评估等方面加强药学监护,提供用药建议,并开展科研工作。Objective:To provide effective points and ideas of pharmaceutical care for clinical pharmacists through retrospective analysis on the use of voriconazole in liver transplantation recipients under 2 years old.Methods:The application of voriconazole in liver transplantation recipients under 2 years old from 2017 to 2019 was investigated and analyzed.Results:In 126 patients,voriconazole was used to prevent or treat invasive fungal disease.The initial dose of voriconazole was 4-6 mg/kg,twice a day,with incidence of adverse reactions of 0.79%.The total therapeutic effective rate in 96 patients with therapeutic administration was 96.8%,and the success rate of prevention in 30 patients with prophylactic administration was 86.67%.Conclusion:Clinical pharmacists can provide evidence-based pharmaceutical suggestions and scientific propaganda by carrying out pharmaceutical care from initial dosage,blood concentration monitoring,dosage adjustment and comprehensive evaluation of key indicators,and scientific research.

关 键 词：伏立康唑 儿童 肝移植 临床药师 药学监护 

分 类 号：R969.3[医药卫生—药理学]