结核病糖尿病共病患者临床特征分析  

Analysis of clinical characteristics of patients with tuberculosis and diabetes mellitus

作　　者：庄严[1] 陈金涛[2] 杜文琼 张艳秋[1] 杨改平[2] 高三友[1] 徐吉英[1] 孙定勇[1] ZHUANG Yan;CHEN Jin-tao;DU Wen-qiong;ZHANG Yan-qiu;YANG Gai-ping;GAO San-you;XU Ji-ying;SUN Ding-yong(Henan Provicial Center for Disease Control and Prevention,Zhengzhou 450016,China;Anyang-Tuberculosis Institute of Anyang city,Anyang,Henan 455000,China)

机构地区：[1]河南省疾病预防控制中心,郑州450016 [2]安阳市结核病防治所,河南安阳455000

出　　处：《医药论坛杂志》2022年第22期71-73,共3页Journal of Medical Forum

基　　金：河南省科技攻关项目(212102310156);河南省医学科技攻关项目(SBGJ202002013)。

摘　　要：目的探讨结核病糖尿病共病患者临床特征及预后,为其临床预防治疗提供理论依据。方法研究对象来自2018年1月至2022年6月在安阳市结核病防治所就诊的结核病患者。依据结核病患者是否合并糖尿病(DM)分为两组即:肺结核病合并糖尿病组(PTB+DM)60人及单纯肺结核病组PTB(90人)。比较两组患者临床特征包括就诊时临床症状、性别、年龄、胸部CT检查、痰培养及淋巴细胞亚群。结果(1)两组患者男性患者比例、就诊临床症状(发热、消瘦、胸闷气短)结果显示差异均有统计学意义(P<0.05);(2)两组患者年龄、就诊时临床症状(咳嗽、乏力、纳差、盗汗)相比较无统计学意义(P>0.05);(3)PTB+DM组患者(痰培养阳性、形成空洞、病变范围≥3个肺叶)显著高于单纯PTB组(P<0.05);(4)两组患者外周血淋巴细胞亚群绝对计数比较均无统计学差异(P>0.05)。结论男性PTB有发热、消瘦、胸闷气短,病灶范围广泛时要及时检测是否并发糖尿病,及早发现PTB+DM,积极落实PTB+DM综合性治疗。Objective To explore the clinical characteristics and prognosis of patients with comorbidity of tuberculosis and diabetes,and provide theoretical basis for their clinical prevention and treatment.Methods The study subjects were patients with tuberculosis who visited the Anyang-Tuberculosis Institute of Anyang city from January 2018 to June 2022.According to whether tuberculosis patients were complicated with diabetes(DM),they were divided into two groups,i.e.60 patients in the pulmonary tuberculosis complicated with diabetes group(PTB+DM)and 90 patients in the simple pulmonary tuberculosis group(PTB).The clinical characteristics of the two groups were compared,including clinical symptoms,sex,age,chest CT examination,sputum culture and lymphocyte subsets.Results(1)The proportion of male patients and the clinical symptoms(fever,weight loss,chest tightness and shortness of breath)in the two groups were statistically significantly different(P<0.05);(2)The age of the two groups,the clinical symptoms at the time of consultation(cough,fatigue,anorexia,night sweats)were not statistically significant(P>0.05);(3)The patients in the PTB+DM group(positive sputum culture,cavity formation,and lesions≥3 lobes)were significantly higher than those in the simple PTB group(P<0.05);(4)There was no statistical difference in the absolute counts of peripheral blood lymphocyte subsets between the two groups(P>0.05).Conclusion Male PTB has fever,weight loss,chest tightness,shortness of breath and extensive of lesions,it is necessary to timely detect whether it is complicated by diabetes,detect PTB+DM as soon as possible,and actively implement comprehensive treatment of PTB+DM.

关 键 词：肺结核 糖尿病 就诊临床症状 淋巴细胞亚群 痰培养 

分 类 号：R52[医药卫生—内科学]