特布他林联合布地奈德雾化吸入治疗AECOPD的临床疗效及对患者气道炎性因子水平的影响  

Clinical efficacy of terbutaline combined with budesonide aerosol inhalation in the treatment of AECOPD and its influence on the level of airway inflammatory factors

作　　者：林辛锋 吴翔 史洪辉 LIN Xinfeng;WU Xiang;SHI Honghui(Department of Respiratory and Critical Care Medicine,the First Hospital Affiliated to Fujian Medical University,Fujian province,Fuzhou 350009,China)

机构地区：[1]福建医科大学附属福州市第一医院呼吸与危重症医学科,福州市350009

出　　处：《临床合理用药杂志》2022年第34期13-16,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察特布他林联合布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及对患者气道炎性因子水平的影响。方法选取2020年5月—2021年5月福建医科大学附属福州市第一医院收治的AECOPD患者80例,采用随机数字表法分为观察组和对照组,每组40例。对照组患者在常规治疗基础上使用布地奈德雾化吸入治疗,观察组患者使用特布他林联合布地奈德雾化吸入治疗,2组患者均治疗1周。比较2组患者治疗效果,治疗前后血清炎性因子水平、肺功能及血气指标。结果观察组患者的治疗总有效率为95.00%,显著高于对照组的70.00%(χ^(2)=8.658,P=0.003)。治疗1周后,2组患者肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)水平较治疗前均下降,且观察组均低于对照组(P<0.01);2组患者呼气流量峰值(PEF)、第1秒用力呼气量(FEV_(1))、用力肺活量(FVC)和FEV_(1)/FVC较治疗前均升高,且观察组均高于对照组(P<0.05或P<0.01);2组患者动脉血氧分压(PaO_(2))较治疗前升高,动脉血二氧化碳分压(PaCO_(2))较治疗前降低,且观察组变化幅度大于对照组(P<0.01)。结论特布他林联合布地奈德雾化吸入治疗AECOPD不仅可显著提高患者治疗有效率,减轻机体炎性反应,还可提高肺功能,改善血气指标,整体治疗效果较好,值得临床推广。Objective To observe the clinical efficacy of terbutaline combined with budesonide aerosol inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its influence on the level of airway inflammatory factors.Methods From May 2020 to May 2021,80 patients with AECOPD who were admitted to Fuzhou First Hospital Affiliated to Fujian Medical University were selected,they were randomly divided into observation group and control group with 40 patients in each group.The patients in the control group were treated with budesonide aerosol inhalation on the basis of conventional treatment,and the patients in the observation group were treated with terbutaline combined with budesonide aerosol inhalation,the patients in both groups were treated for one week.The therapeutic effect,serum inflammatory factor level,pulmonary function and blood gas index were compared between the two groups before and after treatment.Results The total effective rate of patients in the observation group was 95.00%,significantly higher than 70.00%in the control group(χ^(2)=8.658,P=0.003).One week after treatment,the tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)levels decreased compared with those before treatment,the observation group were lower than the control group(P<0.01);The peak expiratory flow(PEF),forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC)and FEV_(1)/FVC in both groups were higher than those before treatment,and observation group were higher than those in the control group(P<0.05 or P<0.01);The partial pressure of arterial blood oxygen(PaO_(2))increased and the partial pressure of arterial blood carbon dioxide(PaCO_(2))decreased in the two groups than before treatment,and the change range in the observation group were greater than those in the control group(P<0.01).Conclusion Terbutaline combined with budesonide aerosol inhalation in the treatment of AECOPD can not only significantly improve the treatment efficiency of patients,reduc

关 键 词：慢性阻塞性肺疾病 急性加重期 特布他林 布地奈德 雾化吸入 临床疗效 炎性因子 

分 类 号：R563.9[医药卫生—呼吸系统]