卵泡输出率与血清let-7g、let-7f联合评估超促排卵卵巢反应及临床意义  

Value and clinical significance of follicular output rate combined with serum let-7g and let-7f levels for evaluating ovarian response to controlled ovarian hyperstimulation

作　　者：赵秀红[1] 宋姝君 ZHAO Xiuhong;SONG Shujun(Zibo Maternal and Child Health Care Hospital,Zibo,Shandong Province,255000)

机构地区：[1]山东省淄博市妇幼保健院,255000

出　　处：《中国计划生育学杂志》2023年第1期37-42,共6页Chinese Journal of Family Planning

摘　　要：目的:研究卵泡输出率(FORT)与血清let-7g、let-7f联合评估超促排卵患者卵巢反应价值及临床意义。方法:收集本院2020年1月-2021年12月行体外受精-胚胎移植术(IVF-ET)患者97例临床资料,根据患者获卵数分为卵巢低反应组、中反应组及高反应组,比较3组FORT、血清let-7g、let-7f水平,分析不同妊娠结局及FROT水平患者临床特征、促排卵效果、实验室指标及治疗结局,分析FORT、血清let-7g及let-7f评估患者卵巢反应性价值。结果:血清let-7g、let-7f水平卵巢中反应组高于低反应组及高反应组(P<0.05),低反应组与高反应组无差异(P>0.05);FORT水平在低反应组、中反应组及高反应组依次升高(P<0.05)。妊娠组血清let-7g、let-7f、FORT、获卵数、受精率及优质胚胎率均高于非妊娠组(P<0.05);低FROT组AFC数低于中FROT组及高FROT组(P<0.05),低FROT组、中FROT组及高FROT组获卵数、受精率、优质胚胎率及临床妊娠率依次升高(P<0.05)。患者血清let-7g与let-7f水平呈正相关,两者与TORF无明显相关性。FORT、血清let-7g及let-7f单独应用时,预测卵巢低反应性或高反应性的价值均以let-7f最高(AUC=0.754、0.767),其次是FORT(AUC=0.750、0.734),3项指标联合应用(AUC=0.859、0.848)提高了评估效能。结论:FORT及血清let-7g、let-7f miRNA表达在反映卵巢反应性中均具一定效能,可作为指导控制性超排卵方案制定的潜在指标。Objective:To study the value and clinical significance of follicular output rate(FORT)combined with serum let-7f levels for evaluating ovarian response to controlled ovarian hyperstimulation(COH).Methods:The clinical data of 97 women who underwent in vitro fertilization-embryo transfer(IVF-ET)due to the factors of fallopian tube or male from January 2020 to December 2021 were collected.These women were divided into group A(women with low ovarian response),group B(women with medium ovarian response),and group C(women with high ovarian response)according to the number of oocytes retrieved.The FORT,and the serum let-7g and let-7f levels of the women were compared among the three groups.The clinical characteristics,the effect of ovulation induction,the laboratory indicators,and the treatment outcomes of the women with different pregnancy outcomes and FORT were analyzed.The value of FORT,and the levels of serum let-7g and let-7f for evaluating the ovarian response of these women was analyzed.Results:The levels of serum let-7g and let-7f of the women in group B were significantly higher than those of the women in groups A and C(P<0.05),but which of the women had no significant difference between group A and group C(P>0.05).The FORT of the women in group A,B,and C had increased gradually(P<0.05).The serum let-7g and let-7f level,the FORT,the number of eggs obtained,the fertilization rate,and the good quality embryo rate of the women with pregnancy were significantly higher than those of the women without pregnancy(P<0.05).The AFC number of the women with low FROT was significantly lower than that of the women with medium FROT or with high FROT(P<0.05),and the number of eggs obtained,the fertilization rate,the good embryo rate,and the clinical pregnancy rate of the women with low FROT,middle FROT,and high FROT had increased gradually(P<0.05).The serum let-7g level of the women were positively correlated with their et-7flevel,but the serum let-7g and let-7f levels of the women were not significantly correlated with their

关 键 词：体外受精-胚胎移植 控制性超排卵 卵巢反应性 卵泡输出率 血清let-7g 血清let-7f 评估价值 

分 类 号：R714.8[医药卫生—妇产科学]