肥胖型多囊卵巢综合征患者自我体重管理对体外受精-胚胎移植后妊娠结局的影响  

Influence of self-weight management of obese women with polycystic ovary syndrome on their pregnancy outcomes after in vitro fertilization-embryo transfer

作　　者：梅艳芳[1] 党翠玲 石彪[1] 程明艳 谌海娟 王雪岩 MEI Yanfang;DANG Cuiling;SHI Biao;CHENG Mingyan;CHEN Haijuan;WANG Xueyan(Chengde Central Hospital,Chengde,Hebei Province,067000)

机构地区：[1]河北省承德市中心医院,067000

出　　处：《中国计划生育学杂志》2023年第1期52-55,共4页Chinese Journal of Family Planning

基　　金：承德市科技计划项目(202102A008)。

摘　　要：目的:探讨肥胖型多囊卵巢综合征(PCOS)患者自我体重管理对体外受精-胚胎移植(IVF-ET)后妊娠结局的影响。方法:采用便利抽样法,选取2019年1月-2021年12月本院就诊拟行IVF-ET肥胖型PCOS患者108例,随机数字表均分为管理组(n=54)与对照组(n=54),两组均常规药物治疗,管理组行自我体重管理,观察两组体质指数(BMI)、促性腺激素(Gn)Gn使用时间及用量、获卵数、脂联素、瘦素受体、抵抗素、瘦素、受精率、优胚率、种植率及妊娠率等差异,对比妊娠结局。结果:干预后,管理组BMI(24.8±1.5 kg/m^(2))、Gn使用时间(10.7±1.3d)、Gn用量(1856.8±74.0IU)均低于对照组(27.6±1.8 kg/m^(2)、13.1±1.6 d、2483.6±78.4IU),获卵数(16.35±2.51枚)高于对照组(16.4±2.5枚),脂联素(1.41±0.87ng/ml)、瘦素受体(3.40±1.14)均高于对照组(0.97±0.62 ng/ml、2.97±0.88),抵抗素(24.52±1.41ng/ml)、瘦素(0.31±0.13mg/ml)均低于对照组(27.12±1.84 ng/ml、0.43±0.15 mg/ml),受精率(85.2%)、优胚率(59.3%)、种植率(46.3%)、妊娠率(48.2%)均高于对照组(72.2%、44.4%、24.1%、27.8%)(均P<0.05)。结论:自我体重管理可有效降低肥胖型PCOS患者体质量,提高治疗效果,改善妊娠结局。Objective:To investigate the influence of self-weight management of obese women with polycystic ovary syndrome(PCOS)after in vitro fertilization-embryo transfer(IVF-ET)on their pregnancy outcomes.Methods:The convenience sampling method was used to select 108 obese women with PCOS who planned to receive IVF-ET in this study from January 2019 to December 2021.These women were divided into observation group(n=54)and control group(n=54)according to the random number table.The women in the control group were given conventional drug treatment,and the women in the observation group were given self-weight management based on treatment of the control group.The differences of body mass index(BMI),the time and dosage of gonadotropin hormone(Gn),the number of eggs obtained,the levels of adiponectin,leptin receptor,resistin,and leptin,and the rates of fertilization,optimal embryo,embryo implantation,and pregnancy of the women in the two groups were observed.The pregnancy outcomes of the women were compared between the two groups.Results:After treatment,The BMI value(24.8±1.5kg/m^(2)),the duration of Gn used(10.7±1.3d),and the dosage of Gn used(1856.8±74.0IU)of the women in the observation group were significantly lower than those(27.6±1.8kg/m^(2),13.1±1.6d,and 2483.6±78.4IU)of the women in the control group.The number of eggs obtained(16.35±2.51),and the levels of adiponectin(1.41±0.87ng/ml)and leptin receptor(3.40±1.14)of the women in the observation group were significantly higher than those(16.4±2.5,0.97±0.62ng/ml,and 2.97±0.88)of the women in the control group.The levels of resistin(24.52±1.41ng/ml)and leptin(0.31±0.13mg/ml)of the women in the observation group were significantly lower than those(27.12±1.84ng/ml and 0.43±0.15mg/ml)of the women in the control group.The fertilization rate(85.2%),the optimal embryo rate(59.3%),the implanting rate(46.3%),and the pregnancy rate(48.2%)of the women in the observation group were significantly higher than those(72.2%,44.4%,24.1%,and 27.8%)of the women in the contro

关 键 词：多囊卵巢综合征 肥胖 体外受精-胚胎移植 自我体重管理 临床指标 妊娠结局 

分 类 号：R711.75[医药卫生—妇产科学] R714.8[医药卫生—临床医学]