喉咳方加减治疗阴虚火旺型喉源性咳嗽的临床观察  

Clinical Efficacy of Modified Houke Decoction on Laryngeal Cough with Yin Deficiency and Fire Hyperactivity Syndrome

作　　者：赵梦迪 薛明[2] ZHAO Meng-di;XUE Ming(Shanghai University of Traditional Chinese Medicine,Shanghai 200120;Shanghai TCM-Integrated Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200082)

机构地区：[1]上海中医药大学,上海200120 [2]上海中医药大学附属市中西医结合医院,上海200082

出　　处：《世界中西医结合杂志》2022年第12期2464-2468,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：上海市虹口区“国医强优”三年行动计划中医药服务体系项目(HGY-YSZK-2018-05)。

摘　　要：目的观察喉咳方加减治疗阴虚火旺型喉源性咳嗽的临床疗效。方法选取2021年4月—2021年12月期间上海市中西医结合医院耳鼻咽喉科门诊收治的阴虚火旺型喉源性咳嗽患者70例,按随机数字表法分为对照组和治疗组,每组各35例。治疗组以喉咳方加减治疗,对照组予以清喉利咽颗粒治疗。治疗2周后,观察比较两组患者临床疗效及治疗前后视觉模拟评分(Visual analogue scale,VAS)、电子喉镜评分、中医证候评分及莱斯特咳嗽生活质量问卷(The Leicester Cough Questionnaire in Mandarin-Chinese,LCQ-MC)评分。结果治疗2周后及停药2周后两组患者VAS评分均较治疗前降低,差异有统计学意义(P<0.05);对照组停药2周后与治疗2周后评分比较,差异有统计学意义(P<0.05);治疗组停药2周后评分略低于治疗2周,差异无统计学意义(P>0.05);治疗2周后及停药2周后治疗组VAS评分均低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后电子喉镜评分比较,差异无统计学意义(P>0.05)。治疗2周后及停药2周后两组患者中医证候评分均较治疗前降低,差异有统计学意义(P<0.05);停药2周后对照组中医证候评分与治疗2周后比较,差异有统计学意义(P<0.05);停药2周后治疗组中医证候评分与治疗2周后比较,差异无统计学意义(P>0.05);治疗2周后及停药2周后治疗组中医证候评分均较对照组降低,差异有统计学意义(P<0.05)。治疗2周后两组患者LCQ-MC评分均较治疗前升高,差异有统计学意义(P<0.05);且治疗组LCQ-MC评分明显高于对照组,差异有统计学意义(P<0.05)。治疗2周后治疗组总有效率88.57%(31/35)明显高于对照组74.29%(26/35),差异有统计学意义(P<0.05)。结论喉咳方加减可明显改善阴虚火旺型喉源性咳嗽患者临床症状。Objective To explore the clinical efficacy of modified Houke Decoction in the treatment of laryngeal cough with yin deficiency and fire hyperactivity syndrome.Methods Seventy outpatients diagnosed with laryngeal cough(yin deficiency and fire hyperactivity syndrome)in the Department of Otorhinolaryngology,Shanghai TCM-Integrated Hospital from April 2021 to December 2021 were enrolled and divided into a control group(n=35)and a treatment group(n=35)according to the random number table method.The patients in the treatment group were treated with modified Houke Decoction,while those in the control group with Qinghou Liyan Granules.After two weeks of treatment,the clinical efficacy,visual analogue scale(VAS)scores,electronic laryngoscope scores,TCM syndrome scores,and the Leicester Cough Questionnaire in Mandarin-Chinese(LCQ-MC)scores before and after treatment were observed and compared between the two groups.Results After two weeks of treatment and two weeks of drug withdrawal,VAS scores of the two groups were lower than those before treatment(P<0.05).In the control group,the score after two weeks of drug withdrawal was significantly different from that after two weeks of treatment(P<0.05).In the treatment group,the score after two weeks of drug withdrawal was slightly lower than that after two weeks of treatment(P>0.05).VAS scores in the treatment group were lower than those in the control group after two weeks of treatment and two weeks of drug withdrawal(P<0.05).There was no significant difference in the electronic laryngoscope score between the two groups before and after treatment(P>0.05).After two weeks of treatment and two weeks of drug withdrawal,TCM syndrome scores of the two groups were lower than those before treatment(P<0.05).In the control group,the TCM syndrome score after two weeks of drug withdrawal was significantly different from that after two weeks of treatment(P<0.05).In the treatment group,there was no significant difference in TCM syndrome score after two weeks of drug withdrawal and after two

关 键 词：喉源性咳嗽 喉咳方 阴虚火旺型 

分 类 号：R256.11[医药卫生—中医内科学]