基于数据挖掘(新角度)探讨刘红旭教授验方“心痛三两三”治疗稳定性冠心病的运用特点  

Data Mining-based Analysis on Application of Professor Liu Hongxu′s Prescription Xin Tong-San Liang San(XTSLS)in the Treatment of Stable Coronary Heart Disease

作　　者：龙德怀 尚菊菊[1] 刘红旭[1] 周明学[1,2] 来晓磊[1] 连妍洁 LONG De-huai;SHANG Ju-ju;LIU Hong-xu;ZHOU Ming-xue;LAI Xiao-lei;LIAN Yan-jie(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010;Beijing Institute of Traditional Chinese Medicine,Beijing 100010)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]北京市中医研究所,北京100010

出　　处：《世界中西医结合杂志》2022年第10期1913-1918,1926,共7页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金项目(82174315);国家中医药管理局中医药循证能力建设项目(2019XZZX-XXG001)。

摘　　要：目的探讨刘红旭教授验方“心痛三两三”在治疗稳定性冠心病中的运用规律。方法通过数据挖掘分析首都医科大学附属北京中医医院刘红旭教授门诊近10年诊治有效的稳定性冠心病处方数据。结果共纳入方剂3627首,涉及药物278味,药物使用频次61479次。“心痛三两三”方中延胡索、当归、鸡血藤、川芎用药频次分列第4、6、7、11位;“心痛三两三”方皆为温性药,五味属辛、甘、苦之类,归经以肝、心、脾为主,功效以活血化瘀为主,皆与整体方药体系相顺应;关联规则分析发现“心痛三两三”方中的其他4味中药同时出现时,川芎随之出现的概率为100%,鸡血藤出现的概率为96.73%,当归出现的概率为91.78%,延胡索出现的概率为83.01%,三七粉或水蛭出现的概率和为62.45%;显示三七粉出现时,水蛭随之出现的概率为41.18%,忍冬藤出现时,鸡血藤随之出现的概率为44.51%;“提升度”前20的药对中,与“心痛三两三”方或其常用加减药物相关的药对占14对;系统聚类分析显示当归、川芎、鸡血藤、三七粉4味药物单独为一聚类项。结论验方“心痛三两三”组成药物在整体方药体系中具有与整体方药体系相顺应,使用频次高,药物间关联性强,方中药物间主次分明及随症加减灵活变换的特点,是刘红旭教授治疗稳定性冠心病方药体系的核心方之一。Objective To explore the application rule of Professor Liu Hongxu′s prescription Xin Tong-San Liang San(XTSLS)in the treatment of stable coronary heart disease.Methods Data mining was performed for the effective treatment cases of stable coronary heart disease in the outpatient clinic of Professor Liu Hongxu in Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University during the past 10 years.Results A total of 3627 prescriptions were included in this study,involving 278 herbal medicines,which showed the use frequency of 61479 times.Corydalis Rhizoma,Angelicae Sinensis Radix,Spatholobi Caulis,and Chuanxiong Rhizoma in the prescriptions were ranked 4 th,6 th,7 th,and 11 th in terms of frequency of use.The herbs constituting XTSLS have warm nature,pungent,sweet or bitter taste,tropism to the liver,heart,and spleen meridians,and the main activities of activating blood and resolving stasis,which are in line with the overall prescription system.The association rules analysis revealed that when the other four herbs in the prescription appeared at the same time,the appearance probabilities of Chuanxiong Rhizoma,Spatholobi Caulis,Angelicae Sinensis Radix,Corydalis Rhizoma,and Notoginseng Radix et Rhizoma/Hirudo were 100%,96.73%,91.78%,83.01%,and 62.45%,respectively.In the presence of Notoginseng Radix et Rhizoma,the appearance probability of Hirudo was 41.18%.In the presence of Lonice Raejaponicae Caulis,the appearance probability of Spatholobi Caulis was 44.51%.Among the top 20 herb pairs in terms of lift,14 pairs were associated with XTSLS or modified XTSLS.The systematic cluster analysis showed that Angelicae Sinensis Radix,Chuanxiong Rhizoma,Spatholobi Caulis,and Notoginseng Radix et Rhizoma were clustered into a clade.Conclusion XTSLS has the characteristics of conforming to the overall prescription system,high frequency of use,strong correlation between herbs,clear priority between herbs in prescription and flexible modification with syndrome,which is one of the core prescriptions

关 键 词：稳定性冠心病 心痛三两三 数据挖掘 刘红旭 

分 类 号：R541.4[医药卫生—心血管疾病]