基于聚类分析对体外受精与胚胎移植控制性超促排前后多囊卵巢综合征不孕症中医证候的研究  

Influence of IVF-ET Controlled Ovarian Hyperstimulation on Traditional Chinese Medicine Syndromes of Infertile Patients with Polycystic Ovary Syndrome Based on Cluster Analysis

作　　者：杨玉培 宋亚静 刘杨杰 杜惠兰[1] YANG Yu-pei;SONG Ya-jing;LIU Yang-jie;DU Hui-lan(Hebei University of Chinese Medicine,Shijiazhuang Hebei 050091;Hebei Yiling Hospital,Shijiazhuang Hebei 050000;Beijing Emergency Medical Center,Beijing 100031)

机构地区：[1]河北中医学院,河北石家庄050091 [2]河北以岭医院,河北石家庄050000 [3]北京急救中心,北京100031

出　　处：《世界中西医结合杂志》2022年第10期2024-2028,2034,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省教育厅在读研究生创新能力培养资助项目(XCXZZSS2019002)。

摘　　要：目的研究体外受精与胚胎移植(In Vitro Fertilization and Embryo Transfer,IVF-ET)控制性超促排(Controlled Ovarian Hyperstimulation,COH)对多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)不孕症患者中医证候的影响。方法选取2018年1月—2019年12月期间就诊于河北中医学院门诊部、河北省中医院行IVF-ET控制性超促排的97例PCOS不孕症患者。设计信息采集表,对97例IVF-ET控制性超促排治疗的PCOS不孕症患者进行中医四诊信息收集,运用频数分析、聚类分析等方法进行统计分析,探讨COH治疗前后中医证候、病位分布规律。结果PCOS不孕症患者COH治疗前证候为气滞证(41.18%)、肾阴虚证(23.53%)、脾虚痰湿证(9.8%)、肾阳虚兼气滞证(5.88%)、其他证(19.61%);COH治疗后为肾虚肝郁证(63.04%)、肾阳虚兼气滞证(10.87%)、脾阳虚兼气滞证(8.70%)、肾气阴两虚证(6.52%)、其他证(10.87%)。在中医单证上,PCOS不孕症患者以气滞证为主,COH治疗后以气滞证、阴虚证为主。PCOS不孕症患者COH治疗前后病位均以肝、肾为主。结论PCOS不孕症患者中医证候分布在COH治疗前以气滞证主,治疗后以肾虚肝郁证为主。Objective To study the effect of in vitro fertilization and embryo transfer(IVF-ET)controlled ovarian hyperstimulation(COH)on traditional Chinese medicine(TCM)syndromes of infertile patients with polycystic ovary syndrome(PCOS).Methods An information collection table was designed to collect the data of the four TCM examinations(looking,listening and smelling,asking and touching)of 97 infertile PCOS patients treated with IVF-ET COH in the outpatient clinic of Hebei University of Chinese Medicine and Hebei Province Hospital of Traditional Chinese Medicine from January 2018 to December 2019.Frequency analysis,cluster analysis and other methods were conducted to explore the distribution of TCM syndromes and disease location before and after COH treatment.Results The syndromes of infertile PCOS patients before COH treatment were Qi stagnation(41.18%),kidney Yin deficiency(23.53%),spleen deficiency and phlegm-dampness(9.8%),kidney yang deficiency combined with qi stagnation(5.88%),and others(19.61%).After COH treatment,the syndromes were kidney deficiency and liver depression(63.04%),kidney yang deficiency combined with qi stagnation(10.87%),spleen yang deficiency combined with qi stagnation(8.70%),kidney qi and yin deficiency(6.52%),and others(10.87%).In terms of single TCM syndrome,infertile PCOS patients mainly presented qi stagnation,and after COH treatment,qi stagnation and yin deficiency were dominant.Liver and kidney were the main disease locations of infertile PCOS patients before and after COH treatment.Conclusion Infertile PCOS patients mainly had qi stagnation before COH treatment,while after treatment,kidney deficiency and liver depression was the main syndrome.

关 键 词：体外受精与胚胎移植(IVF-ET) 控制性超促排(COH) 多囊卵巢综合征(PCOS) 不孕症 中医证候 聚类分析 

分 类 号：R271.14[医药卫生—中医妇科学]