不同剂量布地奈德雾化吸入治疗儿童哮喘急性发作对肺功能及炎症因子水平的影响  

Effects of Different Dose Levels of Budesonide Aerosol Inhalation on Pulmonary Function and Inflammatory Factors in Children with Acute Asthma

作　　者：孙俭[1] 张晓[1] 杨贤 SUN Jian;ZHANG Xiao;YANG Xian(Third Department of pediatrics,Nanyang First People’s Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院儿三科,南阳473000

出　　处：《中国合理用药探索》2023年第1期60-64,共5页Chinese Journal of Rational Drug Use

摘　　要：目的:探讨不同剂量布地奈德雾化吸入治疗儿童哮喘急性发作期的临床疗效。方法:选取2020年1月~2021年12月期间于本院接受治疗的120例哮喘患儿作为研究对象,采用随机数字表法分为0.5mg剂量组与1.0mg剂量组,每组60例。0.5mg剂量组予以0.5mg/次布地奈德雾化吸入,1.0mg剂量组予以1.0mg/次布地奈德雾化吸入,连续治疗7天。比较两组临床疗效,症状体征消退时间,第1秒用力呼气容积(FEV1)、呼气流量峰值(PEF)等肺功能指标和白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及白细胞介素-22(IL-22)等血清炎症因子水平。结果:1.0mg剂量组总有效率(96.61%)高于0.5mg剂量组(84.48%,P<0.05);治疗后,1.0mg剂量组呼吸困难、咳嗽、喘息和哮鸣音消退时间均短于0.5mg剂量组(P<0.05);1.0mg剂量组肺功能指标水平均高于0.5mg剂量组(P<0.05),而血清炎症因子水平均低于0.5mg剂量组(P<0.05)。结论:1.0mg/次布地奈德雾化吸入较0.5mg/次剂量能更有效地缓解哮喘患儿症状,改善肺功能,降低炎症因子水平。Objective:To investigate the efficacy of different dose levels of budesonide aerosol inhalation for the treatment of acute asthma in children.Methods:A total of 120 children with asthma who were treated in our hospital from January 2020 to December 2021 were selected.They were randomly assigned into 0.5 mg group and 1.0 mg group by a random number table,with 60 subjects in each group.The 0.5 mg group was treated with 0.5 mg budesonide aerosol inhalation,and the 1.0 mg group was treated with 1.0 mg budesonide aerosol inhalation,both for 7 days.The efficacy,time to symptom/vitalsign recovered,pulmonary function indices such as forced expiratory volume in one second(FEV1),peak expiratory flow(PEF)and serum inflammatory factors such as interleukin-6(IL-6),interleukin-8(IL-8),interleukin-22(IL-22)were compared between the two groups.Results:The overall response rate in 1.0 mg group was 96.61%,which was significantly higher than that in 0.5 mg group(84.48%,P<0.05).Compared with the 0.5 mg group,the time to recovery of dyspnea,cough,pant and wheeze in the 1.0 mg group was significantly shortened(P<0.05).After treatment,the pulmonary function indices in 1.0 mg group were higher than those in 0.5 mg group(P<0.05),while the level of serum inflammatory factor was lower in 1.0 mg group than that in 0.5 mg group(P<0.05).Conclusion:Compared with 0.5mg/dose,1.0mg/dose budesonide inhalation can more effectively alleviate of symptoms in children with asthma,improve pulmonary function,reduce inflammation cytokines level.

关 键 词：支气管哮喘 儿童 布地奈德 肺功能 白细胞介素 

分 类 号：R725.6[医药卫生—儿科]