补阳还五汤加减联合银杏叶提取物注射液治疗缺血性脑卒中的临床疗效及其对神经功能和脂代谢的影响  

Clinical effect of modified Buyanghuanwu decoction combined with ginkgo biloba extract injection for ischemic stroke and its impact on neurological function and lipid metabolism of patients

作　　者：刘慧娴 范翠云 刘可威 LIU Huixian;FAN Cuiyun;LIU Kewei(Department of Neurology,Longmen County People′s Hospital,Huizhou 516800,China)

机构地区：[1]广东省龙门县人民医院神经内科,516800

出　　处：《临床合理用药杂志》2022年第36期9-12,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨补阳还五汤加减联合银杏叶提取物注射液治疗缺血性脑卒中(CIS)的临床疗效及其对患者神经功能及脂代谢的影响,以期为临床治疗提供更多参考。方法选取2020年12月—2021年12月龙门县人民医院收治的CIS患者120例,采用随机数字表法分为对照组60例与研究组60例。对照组采用阿司匹林、银杏叶提取物注射液治疗,研究组在对照组基础上采用补阳还五汤加减治疗,2组疗程均为1个月。比较2组临床疗效,治疗前及治疗1个月血脂指标[高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、总胆固醇(TC)]、美国国立卫生研究院卒中量表(NIHSS)评分、脑卒中专用生活质量量表(SS-QOL)评分、中医症候积分及不良反应发生率。结果治疗1个月后,研究组总有效率(95.00%)高于对照组(81.67%)(χ^(2)=5.175,P=0.023)。与治疗前相比,2组治疗1个月后HDL-C水平升高,TG、TC水平降低(P<0.01),且研究组治疗1个月后HDL-C水平高于对照组,TG、TC水平低于对照组(P<0.01)。与治疗前相比,2组治疗1个月后NIHSS评分降低,SS-QOL评分升高(P<0.01),且研究组治疗1个月后NIHSS评分低于对照组,SS-QOL评分高于对照组(P<0.01)。与治疗前相比,2组治疗1个月后肢体麻木、肢倦乏力、头晕头痛积分降低(P<0.01),且研究组治疗1个月后肢体麻木、肢倦乏力、头晕头痛积分低于对照组(P<0.01)。研究组治疗期间不良反应总发生率(8.33%)与对照组(5.00%)比较,差异无统计学意义(χ^(2)=0.134,P=0.714)。结论银杏叶提取物注射液治疗CIS具有一定疗效,但将其与补阳还五汤加减联合治疗的效果更佳,可更有效地改善机体脂代谢水平,减轻患者的神经功能损伤及临床症状,提高生活质量,且安全性较高。Objective To discuss the Clinical effect of modified Buyanghuanwu decoction combined with ginkgo biloba extract injection for ischemic stroke(CIS)and its impact on neurological function and lipid metabolism of patients,in order to provide more references for clinical treatment.Methods A total of 120 cases of CIS patients from December 2020 to December 2021 in Longmen County People′s Hospital,and they were divided into control group with 60 cases and study group with 60 cases by random number table method.Patients in control group were given aspirin and ginkgo biloba extract,and patients in study group were given modified Buyanghuanwu decoction,both groups were treated with 1 month.Clinical effect,blood lipid indexes(HDL-C,TG,TC),NIHSS score,SS-QOL score,TCM symptom score before treatment and at 1 month after treatment,incidence of adverse reactions were compared between the two groups.Results At 1 month after treatment,total effective rate in study group(95.00%)was higher than control group(81.67%)(χ^(2)=5.175,P=0.023).Compared with those before treatment,HDL-C level in the two groups was increased,and levels of TG,TC were decreased at 1 month after treatment(P<0.01),and HDL-C level in study group was higher than that in control group,levels of TG,TC were lower than those in control group at 1 month after treatment(P<0.01).Compared with those before treatment,NIHSS score in the two groups was decreased,SS-QOL score was increased at 1 month after treatment(P<0.01),and NIHSS score in study group was lower than that in control group,SS-QOL score was higher than that in control group at 1 month after treatment(P<0.01).Compared with those before treatment,score of limb numbness,fatigue,dizziness and headache in the two groups were decreased at 1 month after treatment(P<0.01),and score of limb numbness,fatigue,dizziness and headache in study group were lower than those in control group at 1 month after treatment(P<0.01).There was no significant difference of incidence of adverse reactions between the study group(8.3

关 键 词：卒中 缺血性脑卒中 补阳还五汤 银杏叶提取物注射液 神经功能 血脂 

分 类 号：R277.7[医药卫生—中医学]