维生素缺乏状况对围绝经妇女焦虑抑郁情绪影响的研究  

Effect of vitamin deficiency on anxiety and depression in perimenopausal women

作　　者：冯娜 阿不来提·艾则孜[1] 程静 姚翼青[1] FENG Na;ABULAITI Aizezi;CHENG Jing;YAO Yiqing(Department of General Medicine,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,Xinjiang,China)

机构地区：[1]新疆维吾尔自治区人民医院全科医疗科,乌鲁木齐830001

出　　处：《中国性科学》2023年第1期56-59,共4页Chinese Journal of Human Sexuality

基　　金：新疆维吾尔自治区自然科学基金(2019D01C064)。

摘　　要：目的 分析维生素缺乏状况与围绝经期妇女焦虑抑郁情绪的关系。方法 选取2019年3月至2021年5月于新疆维吾尔自治区人民医院体检的127例围绝经期妇女作为研究对象。采用焦虑抑郁量表(HAD)评估患者的焦虑抑郁情绪,并分为焦虑抑郁组(n=33)、无焦虑抑郁组(n=94)。两组均检测维生素(维生素A、B_(1)、B_(9)、B_(12)、C、D、E等)水平,分析维生素缺乏状况与围绝经期妇女焦虑抑郁情绪的关系。结果 127例围绝经期妇女中,有33例伴有焦虑抑郁情绪,占26.19%。焦虑抑郁组维生素B9、B12、D水平低于无焦虑抑郁组,差异具有统计学意义(P<0.05);两组间其他维生素水平比较,差异无统计学意义(P>0.05)。经Logistic回归分析结果显示,维生素B9、B_(12)、D水平升高均可能是围绝经期妇女焦虑抑郁情绪的保护因子(OR<1,P<0.05);绘制受试者工作特征(ROC)曲线发现,维生素B_(9)、B_(12)、D单独检测及联合检测预测围绝经期妇女焦虑抑郁情绪发生风险的曲线下面积(AUC)均>0.80,均有一定预测价值。结论 围绝经期妇女焦虑抑郁情绪可能受维生素B_(9)、B_(12)、D缺乏影响。Objective To analyze the relationship between vitamin deficiency and anxiety and depression in perimenopausal women. Methods 127 cases of perimenopausal women who received physical examination in People′s Hospital of Xinjiang Uygur Autonomous Region from March 2019 to May 2021 were selected as the research subjects, and divided into the anxiety and depression group(n=33) and the non-anxiety and depression group(n=94) by evaluating the anxiety and depression of women with hospital anxiety and depression scale(HAD). The levels of vitamins(vitamin A, B_(1), B_(9), B_(12), C, D, E, etc.) were detected in both group, and the relationship between vitamin deficiency and anxiety and depression of perimenopausal women was analyzed. Results Among 127 perimenopausal women, 33 cases were accompanied with anxiety and depression, accounting for 26.19%;the levels of vitamin B9, B12and D in anxiety and depression group were lower than those in non-anxiety and depression group, the difference was statistically significant(P<0.05);there was no statistical significant difference in other vitamin levels between the two groups(P>0.05). Logistic regression analysis showed that the increase of vitamin B9, B12and D levels might be the protective factor of anxiety and depression in perimenopausal women(OR<1, P<0.05);the receiver operating characteristic(ROC) curve showed that the area under curve(AUC) of vitamin B_(9), B_(12)and D alone and combination in predicting the risk of anxiety and depression in perimenopausal women were all>0.80, which had certain predictive value. Conclusions The anxiety and depression of perimenopausal women may be affected by vitamin B_(9), B_(12)and D deficiency.

关 键 词：围绝经期 维生素缺乏 焦虑抑郁 

分 类 号：R711[医药卫生—妇产科学]