基于“心-肾-胞宫”学说理论下的养心清肝育麟方对卵巢储备功能低下性不孕症患者促排卵效果及性激素水平的影响  

Clinical effect of Yangxin Qinggan Yulin formula based on the theory of "heart-kidney-cell palace" on infertility patients with low ovarian reserve function and its effect on sex hormone level

作　　者：张莉[1] 周丽[1] 唐艳 万朝霞[1] ZHANG Li;ZHOU Li;TANG Yan;WAN Zhaoxia(Department of Gynecology,Nantong Affiliated Hospital,Nanjing University of Chinese Medicine,Nantong 226001,Jiangsu,China)

机构地区：[1]南京中医药大学南通附属医院妇科,江苏南通226001

出　　处：《中国性科学》2023年第1期105-109,共5页Chinese Journal of Human Sexuality

摘　　要：目的 探讨基于“心-肾-胞宫”学说理论下的养心清肝育麟方在卵巢储备功能低下性不孕症患者中的临床应用效果及对性激素水平的影响。方法 选取2018年1月至2019年10月南京中医药大学南通附属医院收治的96例卵巢储备功能低下性不孕症患者作为研究对象。根据系统抽样法随机将其分为对照组和观察组,各48例。对照组予以常规西医药物治疗,观察组在予以常规西医药物治疗的基础上联合基于“心-肾-胞宫”学说理论下的养心清肝育麟方治疗。比较两组治疗后的卵巢储备功能改善情况、性激素水平,以及治疗后1年的妊娠率。结果 治疗后观察组的卵巢面积、卵巢平均直径明显大于对照组,窦卵泡数显著多于对照组,差异具有统计学意义(P<0.05);治疗后,观察组的血清黄体生成素(LH)、卵泡刺激素(FSH)水平明显低于对照组,血清雌二醇(E2)、抗苗勒管激素(AMH)水平显著高于对照组,差异具有统计学意义(P<0.05);治疗后1年,观察组的妊娠率(93.75%)明显高于对照组(75.00%),差异具有统计学意义(P<0.05)。结论 卵巢储备功能低下性不孕症患者采用基于“心-肾-胞宫”学说理论下的养心清肝育麟方联合常规西医药物治疗,能够有效调节性激素水平,改善卵巢储备功能,提高妊娠率。Objective To investigate the clinical effect of Yangxin Qinggan Yulin formula based on the theory of "heart-kidney-cell palace" on infertility patients with low ovarian reserve and its effect on the level of sex hormones. Methods A total of 96 patients with low ovarian reserve infertility who were admitted to the Nantong Affiliated Hospital, Nanjing University of Chinese Medicine from January 2018 to October 2019 were selected as the research objects. They were randomly divided into the control group and the observation group according to the systematic sampling method, with 48 cases in each group. The control group was treated with conventional Western medicine, and the observation group was treated with the combination of Yangxin Qinggan Yulin formula based on the theory of "heart-kidney-cell palace". The improvement of ovarian reserve function, sex hormone levels, and pregnancy rate 1 year after treatment were compared between the two groups. Results After treatment, the ovarian area and mean ovarian diameter of the observation group were significantly higher than that of the control group, and the number of sinus follicles was significantly higher than that of the control group, with statistical significance(P<0.05). After treatment, the levels of luteinizing hormone(LH) and follicle-stimulating hormone(FSH) in serum in observation group were significantly lower than those in the control group, and the levels of estradiol(E2) and anti-müllerian hormone(AMH) in serum were significantly higher than those in control group, with statistical significance(P<0.05). 1 year after treatment, the pregnancy rate in the observation group(93.75%) was significantly higher than that in the control group(75.00%), and the difference was statistically significant(P<0.05). Conclusions For infertile patients with low ovarian reserve function, Yangxin Qinggan Youlin formula based on the theory of "heart-kidney-cell palace" combined with conventional Western medicine can effectively regulate sex hormone levels, improve ovarian res

关 键 词：卵巢储备功能低下 不孕 “心-肾-胞宫”学说 性激素 临床疗效 

分 类 号：R714[医药卫生—妇产科学]