中药调周法联合来曲唑、尿促性素对脾肾两虚型排卵障碍性不孕症患者卵巢功能及妊娠率的影响  

Effects of traditional Chinese medicine menstrual cycle conditioning method combined with letrozole and urinary gonadotropin on ovarian function and pregnancy rate in patients with anovulatory infertility of spleen and kidney deficiency

作　　者：叶金力[1] 邢天伶 李瑞珠[1] 骆杨[1] 李建芹[1] 李清芹[1] YE Jinli;XING Tianling;LI Ruizhu;LUO Yang;LI Jianqin;LI Qingqin(Department of Gynaecology,Beijing Huairou District Hospital of Traditional Chinese Medicine,Beijing 101400,China)

机构地区：[1]北京市怀柔区中医医院妇科,北京101400

出　　处：《中国性科学》2023年第1期128-133,共6页Chinese Journal of Human Sexuality

摘　　要：目的 探究中药调周法联合来曲唑、尿促性素对脾肾两虚型排卵障碍性不孕症患者卵巢功能及妊娠率的影响。方法 选取北京市怀柔区中医医院2018年12月至2020年12月间诊治的92例脾肾两虚型排卵障碍性不孕症患者作为研究对象,随机分成研究组和对照组,各46例。对照组采取西医治疗,研究组采取中医结合西医治疗。比较两组临床疗效、中医症状积分、血清激素水平及排卵率和妊娠率。结果 研究组临床疗效、排卵率及妊娠率均显著高于对照组(P<0.05)。两组治疗后中医症状积分均低于治疗前,且研究组低于对照组(P<0.05);两组治疗后卵泡刺激素(FSH)、雌二醇(E2)、黄体生成素(LH)水平高于治疗前,泌乳素(PRL)、睾酮(T)水平低于治疗前,且研究组FSH、E2、LH水平高于对照组,T、PRL水平低于对照组(P<0.05);两组治疗后子宫内膜厚度、优质卵泡个数及最大卵泡直径均增加,且研究组高于对照组(P<0.05)。结论 排卵障碍性不孕症患者应用中药调周法联合来曲唑、尿促性素治疗,可提高患者的临床疗效及排卵率、妊娠率,并可改善中医症状及卵巢功能。Objective To explore the effects of traditional Chinese medicine menstrual cycle conditioning method combined with letrozole and urinary gonadotropin on ovarian function and pregnancy rate in patients with anovulatory infertility of spleen and kidney deficiency. Methods 92 infertility patients with anovulatory infertility treated in Beijing Huairou District Hospital of Traditional Chinese Medicine from December 2018 to December 2020 were gathered and randomly separated into research group and control group, with 46 cases per group. he control group was treated with western medicine, and the study group was treated with Chinese medicine combined with western medicine. The clinical efficacy, TCM symptom score, serum hormone level, ovulation rate and pregnancy rate were compared between the two groups. Results The curative effect, ovulation rate and pregnancy rate of the study group were obviously higher than those of the control group(P<0.05). The scores of TCM symptoms of the two groups after treatment was lower than that before treatment, and study group had obviously lower scores than control group(P<0.05). After treatment, the levels of follicle-stimulating hormone(FSH), estradiol(E2) and luteinizing hormone(LH) in the two groups were higher than before, and the levels of prolactin(PRL) and testosterone(T) were lower than before, and the levels of FSH, E2and LH in the study group were higher than those in the control group, while the levels of T and PRL were lower than those in the control group(P<0.05). After treatment, endometrial thickness, number of quality follicles and maximum follicle diameter were increased in both groups, and the study group was higher than the control group(P<0.05). Conclusions Traditional Chinese medicine menstrual cycle conditioning method combined with letrozole and urinary gonadotropin can improve the clinical therapeutic effectiveness, ovulation and pregnancy rate of patients with anovulatory infertility.

关 键 词：排卵障碍性不孕症 中药调周法 来曲唑 尿促性素 

分 类 号：R271[医药卫生—中医妇科学]