不稳定型心绞痛患者PCI后冠脉微循环损伤发生状况  

Coronary Microcirculation Injury in Patients with Unstable Angina Pectoris After PCI

作　　者：董智华[1] DONG Zhihua(Three Areas of Cardiovascular Disease,Shangqiu First People’s Hospital,Shangqiu 476100,China)

机构地区：[1]商丘市第一人民医院心血管三病区,河南商丘476100

出　　处：《河南医学研究》2023年第1期112-115,共4页Henan Medical Research

摘　　要：目的 分析不稳定型心绞痛(UAP)患者经皮冠状动脉介入治疗(PCI)后发生冠脉微循环损伤的现状及其影响因素。方法 选取2018年7月至2021年11月商丘市第一人民医院心血管三病区收治的105例UAP患者,均接受PCI治疗。统计患者术后1 d冠脉微循环损伤发生状况,并将其分为发生组与未发生组,由研究者设计临床资料调查表,统计两组临床资料并进行比较,将可能的影响因素纳入,分析导致UAP患者PCI后发生冠脉微循环损伤的相关因素。结果 经PCI治疗后,105例UAP患者中有51例发生冠脉微循环损伤,发生率为48.57%;发生组合并糖尿病占比高于未发生组,预扩张时间长于未发生组,同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平均高于未发生组(P<0.05);经logistic回归分析,结果显示,合并糖尿病、预扩张时间长、Hcy水平高、hs-CRP水平高是UAP患者PCI后出现冠脉微循环损伤的危险因素(OR>1,P<0.05)。结论 UAP患者PCI后冠脉微循环损伤的发生与合并糖尿病、预计扩张时间长、Hcy水平高、hs-CRP水平高有关。Objective To analyze the current situation of coronary microcirculation injury in patients with unstable angina pectoris(UAP) after percutaneous coronary intervention(PCI) and its influencing factors. Methods A total of 105 patients with UAP treated in the Three Areas of Cardiovascular Disease, Shangqiu First People’s Hospital of Shangqiu from July 2018 to November 2021 were selected, and all patients received PCI. The occurrence of coronary microcirculation injury one day after operation was counted and the patients were divided into occurrence group and non occurrence group, and the clinical data questionnaire was designed by the researcher. The clinical data of the two groups were counted and compared, included possible influencing factors, and the influencing factors of coronary microcirculation injury in patients with UAP after PCI were found out. Results After PCI in 105 patients with UAP, 51 cases had coronary microcirculation injury, the incidence rate was 48.57%. Compared with the non occurrence group, the proportion of combined with diabetes mellitus was higher, the pre-expansion time was longer, and the levels of homocysteine(Hcy) and hypersensitive C-reactive protein(hs-CRP) were higher in the occurrence group(P<0.05). Through logistic regression analysis, the results showed that, combined with diabetes mellitus, long pre-expansion time, high Hcy level and high hs-CRP level were the risk factors for coronary microcirculation injury in patients with UAP after PCI(OR>1, P<0.05). Conclusion The risk factors of coronary microcirculation injury in UAP patients after PCI may be related to combined with diabetes mellitus, long time of pre-expansion, high Hcy level and high hs-CRP level.

关 键 词：不稳定型心绞痛 经皮冠状动脉介入治疗 微循环 同型半胱氨酸 超敏C反应蛋白 

分 类 号：R541.1[医药卫生—心血管疾病]