艾滋病抗病毒治疗者疾病感知对抑郁、焦虑影响的前瞻性队列研究  

A prospective cohort study on impact of illness perception on depression and anxiety in patients under HIV antiretroviriral therapy

作　　者：曾静 罗锐 刘聪[2] 李全敏[2] 钟海丹[2] 李凌华[2] 顾菁[1] ZENG Jing;LUO Rui;LIU Cong;LI Quan-min;ZHONG Hai-dan;LI Ling-hua;GU Jing(School of Public Health,Sun Yat-Sen University,Guangzhou,Guangdong 510080,China;不详)

机构地区：[1]中山大学公共卫生学院医学统计系,广东广州510080 [2]广州市第八人民医院感染科

出　　处：《现代预防医学》2023年第1期15-20,共6页Modern Preventive Medicine

基　　金：国家自然科学基金项目(717741784);广东省科学(技术)研究专项(2017A020212006);广州市科学(技术)研究专项一般项目(201607010368)。

摘　　要：目的探讨治疗6个月时的疾病感知与治疗一年后抑郁和焦虑的关系。方法采用前瞻性队列研究方法,于2016年6月至2017年3月通过方便抽样的方法共完成425名新开始抗病毒治疗的患者的招募,收集有效问卷400份,6个月和12个月时分别完成随访348人和304人。最终纳入分析304人,采用logistic回归分别分析疾病感知与抑郁及焦虑之间的关系。结果接受抗病毒治疗12个月后具有显著抑郁症状和焦虑症状的患者占比分别为23.0%和14.9%。疾病感知总分为(37.48±9.73)分。治疗过程中的疾病感知总分(OR=1.11,95%CI:1.04~1.18)、疾病可理解性(OR=0.83,95%CI:0.70~0.99)和疾病情绪(OR=1.38,95%CI:1.16~1.62)是抑郁的预测因素。疾病感知总分(OR=1.14,95%CI:1.05~1.25)、疾病影响(OR=1.47,95%CI:1.16~1.85)和疾病情绪(OR=1.75,95%CI:1.32~2.33)是焦虑的预测因素。结论接受抗病毒治疗一年后患者的焦虑及抑郁状况仍有待改善,可采取针对性干预措施改善疾病感知水平,从而改善长期的心理健康。Objective To explore the relationship between illness perception at 6 months after antiretroviral therapy(ART)and depression and anxiety at one year after ART.Methods A prospective cohort study was conducted from June 2016 to March 2017.A total of 425 patients who newly initiated ART were recruited by convenience sampling method,and 400 valid questionnaires were collected.Of 400 participants,348 and 304 were followed up at 6 and 12 months,respectively.Finally,304 people were included in the analysis.Logistic regression was used to analyze the relationship between illness perception and depression and anxiety respectively.Results The proportion of participants with depressive symptoms and anxiety symptoms at 12 months after ART was 23.0%and 14.9%,respectively.The total score of illness perception was 37.48±9.73.The total score of illness perception score(OR=1.11,95%CI:1.04-1.18)and illness comprehensibility(OR=0.83,95%CI:0.70-0.99)and emotion(OR=1.38,95%CI:1.16-1.62)during ART was the predictor of depression.The total score of illness perception score(OR=1.14,95%CI:1.05-1.25)and consequence(OR=1.47,95%CI:1.16-1.85)and emotion(OR=1.75,95%CI:1.32-2.33)was the predictor of anxiety.Conclusion Anxiety and depression of patients at one year after ART still need to be improved,and targeted interventions are needed to improve the level of illness perception,so as to improve long-term mental health.

关 键 词：抗病毒治疗 疾病感知 HIV/AIDS 心理健康 

分 类 号：R395.1[哲学宗教—心理学]