MiR-139-5p的研究进展  

Research progress of miR-139-5p

作　　者：方韶韩 朱晓雷 张潇文[2] 冯义辉 李宁[1] 耿国军[1] FANG Shaohan;ZHU Xiaolei;ZHANG Xiaowen;FENG Yihui;LI Ning;GENG Guojun(Department of Thoracic Surgery,The First Affiliated Hospital of Xiamen University,Xiamen,360000,Fujian,P.R.China;Xiamen University,Xiamen,361003,Fujian,P.R.China;Fujian Medical University,Fuzhou,350122,P.R.China)

机构地区：[1]厦门大学附属第一医院胸外科,福建厦门360000 [2]厦门大学,福建厦门361003 [3]福建医科大学,福州350122

出　　处：《中国胸心血管外科临床杂志》2023年第1期149-153,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：MicroRNA是一类非编码且在进化上高度保守的小分子RNA,通过与信使RNA(mRNA)的特异性结合,从而调控基因的表达。目前,关于microRNA的研究已引起全世界的高度重视,其中miR-139-5p表达在癌症的变化发展过程中起着重要作用。在相当一部分癌症中,如肺癌、食管癌、乳腺癌、口腔舌鳞状细胞癌、肝癌,具有抑制癌细胞增殖、转移、侵袭的作用。在癌症治疗中,miR-139-5p可联合部分抗癌药物,延缓抗癌药物的耐药性,以及增强肿瘤对放疗的敏感性,对癌症预后有积极的影响;且其在其它疾病的组织、细胞研究领域中分别起着不同作用,如神经细胞、炎症组织。本文对miR-139-5p的研究现状展开分析。MicroRNAs(miRNAs)are a class of short,highly conserved,non-coding RNA molecules that regulate gene expression by specific binding to the messenger RNAs(mRNAs).At present,the researches on miRNAs have caused immense global concern,and expression of miR-139-5p plays a significant role in tumorigenesis,metastasis and recurrence,through regulating proliferation,migration,and invasion of cancer cells in lung cancer,esophageal cancer,breast cancer,tongue squamous cell carcinoma,hepatocellular carcinoma,etc.MiR-139-5p has a positive impact on the prognosis of cancer,and it can combine with some chemotherapeutic drugs to reverse resistance and enhance the sensitivity of radiotherapy.It also works in the cells and tissues of other diseases,including nerve cells,and inflammation.This article reviewed the progress of miR-139-5p.

关 键 词：MiR-139-5p 癌症 放化疗 炎症 综述 

分 类 号：R346[医药卫生—基础医学]