可改变的心血管危险因素介导动脉粥样硬化的先天性免疫机制研究进展  

Advances in the study of congenital immune mechanisms mediated by modifiable cardiovascular risk factors for atherosclerosis

作　　者：李文韬 李芳卉 李东泽[2] 贾禹 万智[2] 曾锐[1] LI Wentao;LI Fanghui;LI Dongze;JIA Yu;WAN Zhi;ZENG Rui(Department of Cardiology,West China Hospital,Sichuan University,Chengdu,610041,P.R.China;Emergency Department,West China Hospital,Sichuan University,Chengdu,610041,P.R.China)

机构地区：[1]四川大学华西医院心脏内科,成都610041 [2]四川大学华西医院急诊科,成都610041

出　　处：《中国胸心血管外科临床杂志》2023年第1期154-158,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：四川省科学技术项目(2019JDRC0105,2020YFS0154,20SYSX0293);成都市科技局技术创新研发项目(2019-YF05-00322-SN);国家老年疾病临床医学研究中心(四川大学华西医院)项目(Z20191009);四川大学华西医院学科卓越发展1·3·5工程临床研究孵化项目(2018HXFH001,2018HXFH027,20HXFH050)。

摘　　要：肥胖、睡眠障碍、心理压力、久坐不动是可改变的心血管疾病危险因素。越来越多的研究证据表明,这些危险因素可以影响动脉粥样硬化的发生及发展。关于免疫细胞及其相关免疫机制在动脉粥样硬化中作用的研究显示,上述可改变的危险因素可以通过影响骨髓系统的造血功能影响免疫细胞的产生及表型等,进而影响动脉粥样硬化的进展。本文将对可改变的心血管危险因素作用于先天性免疫系统进而影响动脉粥样硬化的进程进行综述。Obesity,sleep disorders,psychological stress,sedentary are modifiable cardiovascular risk factors.There is growing evidence that these risk factors may accelerate the chronic inflammatory process of atherosclerosis and lead to myocardial infarction.Studies on the role of immune cells and their related immune mechanisms in atherosclerosis have shown that the above modifiable risk factors can affect the hematopoiesis of the bone marrow system,affect the production of immune cells and phenotypes,and then affect the progress of atherosclerosis.This review will focus on the effects of modifiable cardiovascular risk factors on the progression of atherosclerosis through the role of the innate immune system.

关 键 词：先天性免疫 动脉粥样硬化 可改变心血管危险因素 骨髓造血 综述 

分 类 号：R54[医药卫生—心血管疾病]