Nrf2/HO-1信号通路在急性肺损伤中的研究进展  

Research progress of Nrf2/HO-1 signaling pathway in acute lung injury

作　　者：孔凯文 孟岩(综述)[1] 邓小明(审校)[1] KONG Kai-wen;MENG Yan;DENG Xiao-ming(Department of Anesthesiology,The First Affiliated Hospital of Naval Medical University/Second Military Medical U-niversity,Shanghai 200433,China)

机构地区：[1]海军军医大学(第二军医大学)第一附属医院麻醉科,上海200433

出　　处：《东南国防医药》2022年第6期646-651,共6页Military Medical Journal of Southeast China

摘　　要：核因子E2相关因子2(Nrf2)是细胞内一种重要的转录因子,被激活后可促进其下游血红素加氧酶-1(HO-1)的表达。HO-1是血红素降解过程的限速酶,能够催化血红素降解为胆绿素、Fe^(2+)和一氧化碳。由于HO-1及其催化产物具有显著的抗氧化和抗炎作用,近些年受到越来越多的关注。最近研究发现,Nrf2/HO-1信号通路在急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)中能够减轻炎症反应和氧化应激损伤,抑制细胞焦亡和铁死亡,进而减轻肺损伤。文章就Nrf2/HO-1信号通路在ALI/ARDS的最新研究成果进行综述。Nuclear factor E2-related factor 2(Nrf2)is a key transcription factor in cells,which can promote the expression of its downstream heme oxygenase-1(HO-1)when activated.HO-1 is the rate-limiting enzyme in the degradation process of heme,which can catalyze the degradation of heme into biliverdin,Fe^(2+)and carbon monoxide.HO-1 and its catalytic products have received more and more attention in recent years due to their significant antioxidant and anti-inflammatory effects.Recent studies have found that Nrf2/HO-1 signaling pathway in ALI/ARDS can reduce the inflammatory response and oxidative stress injury,inhibit cell pyroptosis and ferroptosis,and then reduce lung injury.This article describes the latest research results of Nrf2/HO-1 signaling pathway in ALI/ARDS,in order to provide new therapeutic ideas.

关 键 词：核因子E2相关因子2 血红素加氧酶-1 急性肺损伤 急性呼吸窘迫综合征 

分 类 号：R563[医药卫生—呼吸系统]