癌症化疗患者疲乏相关症状群干预效果的Meta分析  

Effect of fatigue-related symptom cluster management in cancer patients undergoing chemotherapy:a Meta-analysis

作　　者：何聪聪 孟利敏[2] 刘慧珍 黄盼 宁淑艳 徐若媛 林栋美[2] HE Cong-cong;MENG Li-min;LIU Hui-zhen;HUANG Pan;NING Shu-yan;XU Ruo-yuan;LIN Dong-mei(Postgraduate students of Grade 2020,Gannan Medical University;School of Nursing,Gannan Medical University,Ganzhou,Jiangxi 341000;School of Nursing,Wenzhou Medical University,Wenzhou,Zhejiang 325035;Postgraduate students of Grade 2019,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院 [2]赣南医学院护理学院,江西赣州341000 [3]温州医科大学护理学院,浙江温州325035

出　　处：《赣南医学院学报》2022年第11期1193-1201,共9页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(72164001);江西省自然科学基金项目(20202BABL216019);江西省2021年度研究生创新课题(YC2021-S799);江西省教育厅科学技术研究项目(170880)。

摘　　要：目的:系统评价症状群干预对癌症化疗患者疲乏相关症状群严重程度及日常生活干扰程度的影响效果,为减轻癌症化疗患者疲乏相关症状群提供依据。方法:计算机检索CBM、CNKI、万方数据库、维普网、Cochrane Library、PubMed、Web of science及Wiley Online Library,从建库起到2021年6月关于癌症化疗患者疲乏相关症状群干预效果的随机对照试验研究,采用RevMan 5.3、Stata 16.0进行数据分析。结果:11篇文献纳入Meta分析,实验组认知行为干预[SMD=-0.48,95%CI(-0.68,-0.28),P<0.05]、综合干预[SMD=-0.64,95%CI(-0.97,-0.30),P<0.05]及正念减压疗法[SMD=-0.29,95%CI(-0.55,-0.02),P<0.05]对疲乏相关症状群严重程度的改善效果优于对照组;实验组对日常生活干扰程度[SMD=-0.21,95%CI(-0.47,0.05),P>0.05]的改善效果与对照组相比,差异无统计学意义。结论:采用认知行为干预、综合干预及正念减压疗法能够显著改善癌症化疗患者疲乏相关症状群的严重程度,穴位按摩、运动与健康咨询的干预效果尚不明确,症状群管理对患者日常生活干扰程度的改善效果暂时也无法证实。Objective:To systematically evaluate the effect of fatigue-related symptom cluster management on severity and interference in daily life,and to provide evidence for alleviating fatigue-related symptom cluster in cancer patients undergoing chemotherapy.Methods:Randomized controlled trials(RCTs)on the management effect of fatigue-related symptoms in cancer patients undergoing chemotherapy were retrieved by computer from CBM,CNKI,Wanfang database,VIP,the Cochrane Library,PubMed,Web of science and Wiley Online Library from the establishment of the databases to June 2021,RevMan 5.3 software,Stata 16.0 was used for Meta-analysis.Results:Eleven RCTs were included for Meta-analysis.Compared with control group,cognitive behavioral intervention[SMD=-0.48,95%CI(-0.68,-0.28),P<0.05],comprehensive intervention[SMD=-0.64,95%CI(-0.97,-0.30),P<0.05]and mindfulness decompression therapy[SMD=-0.29,95%CI(-0.55,-0.02),P<0.05]improved better;there was no significant difference in the improvement of interference in daily life between the experimental group and the control group[SMD=-0.21,95%CI(-0.47,0.05),P>0.05].Conclusion:Cognitive behavioral intervention,comprehensive intervention and mindfulness decompression therapy can significantly improve the severity of fatigue-related symptoms in cancer chemotherapy patients.The intervention effect of acupoint massage and exercise and health counseling is not clear,while the improvement effect of symptom cluster management on the interference of patients’daily life can not be confirmed.

关 键 词：癌症 化疗 疲乏相关症状群 干预效果 

分 类 号：R473.73[医药卫生—护理学]