抗人类肠道病毒71药物及疫苗研究进展  

Research progress of anti-EV71 drugs and vaccines

作　　者：谢小晖 陈路路 李超英 郑惠丹 张怡 陶玲(综述)[1] 徐银兰(审校) XIE Xiaohui;CHEN Lulu;LI Chaoying;ZHENG Huidan;ZHANG Yi;TAO Ling;XU Yinlan(School of Public Health,Xinxiang Medical University,Xinxiang,Henan 453003,China;School of Foreign Languages,Xinxiang Medical University,Xinxiang,Henan 453003,China)

机构地区：[1]新乡医学院公共卫生学院,河南新乡453003 [2]新乡医学院外语学院,河南新乡453003

出　　处：《现代医药卫生》2023年第2期290-294,共5页Journal of Modern Medicine & Health

基　　金：河南省科学技术厅科技攻关项目(222102310641、222102310701);新乡医学院人才(博士)支持计划项目(XYBSKYZZ202168);河南省高等学校重点科研项目(23A320040)。

摘　　要：手足口病作为一个全球性的公共卫生问题,危害巨大,会引起患儿神经系统疾病,具有高传染性、传播方式多样、病原体复杂多样等特点。引起小儿手足口病的病原体主要为柯萨奇病毒A属和人类肠道病毒71(EV71),作为手足口病主要病原体之一的EV71,感染性极强。目前,已经研制出的抗EV71的有效药物,是预防手足口病的关键途径。该文围绕EV71及抗EV71药物的研究进展进行了综述,进而为今后新药物的研发提供有价值的参考。As a global public health problem, hand, foot and mouth disease(HFMD) is extremely harmful and can cause neurological diseases in children.It has the characteristics of high infectivity, diverse modes of transmission and complex and diverse pathogens.The pathogens causing HFMD in children are mainly Coxsackie virus A and human enterovirus 71(EV71).As one of the main pathogens of HFMD,EV71 is highly infectious.At present, the effective drugs against EV71 have been developed, which is a key way to prevent HFMD.This paper summarized the research progress of EV71 and anti-EV71 drugs, so as to provide valuable reference for the research and development of new drugs in the future.

关 键 词：手足口病 人类肠道病毒71 抗EV71药物 综述 

分 类 号：R512.5[医药卫生—内科学] R373.2[医药卫生—临床医学]