施万细胞在周围神经疾病中的免疫调节研究进展  

Research Progress on immune regulation of Schwann cells in peripheral nerve diseases

作　　者：高曌[1] 骆天炯[1] 宣思(综述) 过伟峰(审校)[2] GAO Zhao;LUO Tianjiong;XUAN Si;GUO Weifeng(Department of Geriatrics,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210022,China;Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210009,China)

机构地区：[1]南京中医药大学附属南京中医院老年病科,江苏南京210022 [2]南京中医药大学,江苏南京210009

出　　处：《现代医药卫生》2023年第2期313-319,共7页Journal of Modern Medicine & Health

摘　　要：施万细胞(SCs)是周围神经系统最丰富的神经胶质细胞。SCs对神经纤维的生物学特性具有动态调节作用,为轴突提供代谢支持。SCs具有高度的分化可塑性,在损伤和疾病时可再分化和去分化,并积极参与再生和炎症过程。SCs在许多病理过程中发挥着重要作用,包括损伤诱导的神经修复、神经退行性疾病、炎症、神经性疼痛和癌症,部分原因是其免疫调节作用。该文围绕近几年开展的关于SCs在周围神经系统损伤和病变时的免疫反应的研究进行了综述。Schwann cells(SCs) are the most abundant glial cells in the peripheral nervous system(PNS).SCs can dynamically regulate the biological characteristics of nerve fibers and provide metabolic support for axons.SCs also have a high degree of differentiation plasticity, can redifferentiate and dedifferentiate in response to injury and disease, and are actively involved in regenerative and inflammatory processes.SCs play an important role in many pathological processes, including injury-induced nerve repair, neurodegenerative diseases, inflammation, neuropathic pain and cancer, in part because of their ability to immune regulation.This review focused on the recent studies on the immune response of SCs to PNS injury and lesion.

关 键 词：施万细胞 周围神经疾病 免疫 综述 

分 类 号：R392.12[医药卫生—免疫学]