绿色前体合成的碳量子点荧光猝灭法快速检测药物中痕量铁离子  

Rapid detection of trace iron ions in drugs by fluorescence quenching of carbon quantum dots synthesized from green precursors

作　　者：喻文湛 李倩 廖微 任静 肖锡林 廖力夫[2] 薛金花[3] YU Wen-zhan;LI Qian;LIAO Wei;REN Jing;XIAO Xi-lin;LIAO Li-fu;XUE Jin-hua(School of Pharmaceutical Science,University of South China,Hengyang 421001,China;School of Chemistry and Chemical Engineering,University of South China,Hengyang 421001,China;School of Public Health,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学药学院,湖南衡阳421001 [2]南华大学化学化工学院,湖南衡阳421001 [3]南华大学公共卫生学院,湖南衡阳421001

出　　处：《应用化工》2022年第12期3453-3457,共5页Applied Chemical Industry

基　　金：国家自然科学基金项目(11475079);湖南省大学生创新创业训练计划项目(2640)。

摘　　要：以樟树叶粉末作为前体,通过水热法一步合成了碳量子点,并以其作为荧光探针建立了检测Fe^(3+)的荧光法。结果表明,在320 nm激发波长下,加入Fe^(3+)反应后碳量子点溶液的荧光强度与未加Fe^(3+)的碳量子点溶液的荧光强度比F/F0与Fe^(3+)浓度在2.72×10^(-5)~1.00×10^(-4)mol/L范围内呈良好的线性关系(R2=0.9912),检出限为8.16μmol/L,将其应用于补铁药中铁含量的测定时,加标回收率为93.08%~105.05%。该碳量子点的制备方法简便快速,原料环保易得,用于Fe^(3+)检测线性良好,灵敏度较高,选择性较好,可用于实际补铁药中铁含量的分析。Carbon quantum dots was synthesized by one-step hydrothermal method using camphor leaves powder as the precursor,and a fluorescent method for Fe^(3+)detection was established by using it as the fluorescent probe.The results show that,at the excitation wavelength of 320 nm,the ratio of fluorescence intensity of CQDs solution after adding Fe^(3+)to CQDs solution without Fe^(3+)addition F/F0and Fe^(3+)concentration shows a good linear relationship in the range of 2.72×10^(-5)~1.00×10^(-4)mol/L(R~2=0.9912),and the limit of detection is 8.16μmol/L.When it is applied to the determination of iron content in iron supplements,the recovery rate of standard addition is 93.08%~105.05%.The preparation method of the carbon quantum dots is simple and fast,the raw material is environmentally friendly and easy to obtain,the method for Fe^(3+)detection has good linearity,high sensitivity and good selectivity,and the carbon quantum dots can be used for the analysis of iron content in actual iron supplements.

关 键 词：碳量子点 铁离子检测 樟树叶 补铁药 

分 类 号：TQ422.2[化学工程]