三亚市孕妇缺铁性贫血与抑郁症的相关性研究  

Study on the relationship between iron deficiency anemia and depression in pregnant women in Sanya city

作　　者：黄颀 曾祥丽 Huang Qi;Zeng Xiangli(Department of Women's Health Care,Sanya Women and Children's Hospital Managed by Shanghai Children’s Medical Center,Hainan,Sanya 572000,China)

机构地区：[1]上海儿童医学中心三亚市妇女儿童医院妇女保健科,海南三亚572000

出　　处：《发育医学电子杂志》2023年第1期38-43,共6页Journal of Developmental Medicine (Electronic Version)

基　　金：海南省临床医学中心建设项目(2021-276)。

摘　　要：目的探讨孕妇缺铁性贫血(iron deiciency anemia,IDA)与抑郁症之间的相关性。方法纳入2020年1月至2021年12月在三亚市妇女儿童医院进行产前检查、资料完整的孕妇共2571例为研究对象。分为IDA组和非IDA组,并对孕妇进行抑郁状态评估。比较IDA组和非IDA组、抑郁症组和非抑郁症组的特征。统计学方法采用t检验、χ^(2)检验、多元逐步Logistic回归分析。结果2571例孕妇中,561例孕妇确诊为IDA,2010例为非IDA。IDA组产次≥1次的孕妇比例(22.99%,129/561)明显低于非IDA组(28.01%,563/2010),两组之间差异具有统计学意义(P<0.05);两组之间在年龄、所在地区、教育水平、工作状况、主动或被动吸烟情况、流产史以及合并疾病情况等方面比较差异均无统计学意义(P>0.05)。在纳入的研究对象中,232例孕妇(232/2571,9.02%)存在抑郁症,抑郁症组IDA孕妇明显高于非抑郁症组,两组间比较差异具有统计学意义[30.17%(70/232)与20.99%(491/2339),P=0.001],IDA程度在两组间差异也具有统计学意义(P=0.006)。多元逐步Logistic回归分析结果显示,IDA(OR=2.717,95%CI:1.301~3.987,P=0.011)、贫血程度(OR=1.227,95%CI:1.035~1.452,P=0.020)、无业/待业(OR=4.151,95%CI:1.283~10.297,P=0.006)、流产史(OR=1.005,95%CI:1.001~1.010,P=0.017)、人工助孕(OR=1.471,95%CI:1.133~1.897,P=0.004)以及合并其他疾病(OR=5.032,95%CI:1.533~13.472,P=0.006)为孕妇抑郁症的危险因素。结论IDA为孕妇发生抑郁症的危险因素,应进行治疗及心理干预,以改善妊娠结局。Objective To investigate the relationship between iron deficiency anemia(IDA)and depression in pregnant women.Method The study included 2571 pregnant women who had completed prenatal examination and information in Sanya Women and Children's Hospital from January 2020 to December 2021.The cases were divided into IDA group and non-IDA group,and the depression status of pregnant women was evaluated.The characteristics of IDA group and non-IDA group and depression and non-depression groups were compared.The statistical method was t test,χ^(2) test,and multiple stepwise Logistic regression analysis.Result Of 2571 pregnant women,561 cases were diagnosed as IDA and 2010 cases were diagnosed as non-IDA.22.99%(129/561)of Pregnant women with≥1 birth in IDA group were significantly lower than 28.01% (563/2 010) in non-IDA group, which was statistical significance (P<0.05). There were no significant differences between the two groups in terms of age, location, education level, work status, active or passive smoking, history of miscarriage, and comorbid diseases (P>0.05). Among the included cases, 232 pregnant women (232/2 571, 9.02%) had depression, and IDA in the depressed group was higher than that in the non-depressed group, with statistical significance [30.17% (70/232) vs 20.99% (491/2 339), P=0.001]. There was also a statistically significant difference in IDA between the two groups (P=0.006). Multivariate stepwise Logistic regression analysis showed that IDA (OR=2.717, 95%CI: 1.301-3.987, P=0.011), the degree of the anemia (OR=1.227, 95%CI: 1.035-1.452, P=0.020), unemployed (OR=4.151, 95%CI: 1.283-10.297, P=0.006), history of miscarriage (OR=1.005, 95%CI: 1.001-1.010, P=0.017), assisted reproductive technologies (OR=1.471, 95%CI: 1.133-1.897, P=0.004) and concomitant other diseases (OR=5.032, 95%CI: 1.533-13.472, P=0.006) were risk factors for the occurrence of depression in pregnant women. Conclusion IDA is a risk factor for depression in pregnant women. Treatment and psychological intervention should be carried o

关 键 词：缺铁性贫血 抑郁症 孕妇 流产 人工助孕 

分 类 号：R714.254[医药卫生—妇产科学] R749.4[医药卫生—临床医学]