淋巴细胞主动免疫治疗对不明原因复发性流产患者的影响  

Effect of Lymphocyte Active Immunity Treatment on Patients with Unexplained Recurrent Spontaneous Abortion

作　　者：周杨 曾瑞珍 郭彩霞 蒋舒静 ZHOU Yang;ZENG Ruizhen;GUO Caixia;JIANG Shujing(The Fourth Affiliated Hospital of Guangzhou Medical University,Guangzhou 511300,China;不详)

机构地区：[1]广州医科大学附属第四医院,广东广州511300

出　　处：《中外医学研究》2023年第1期1-6,共6页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：广州市科技计划项目(202102080547)。

摘　　要：目的:探究淋巴细胞主动免疫治疗对不明原因复发性流产(recurrent spontaneous abortion,RSA)患者的影响。方法:选取2019年7月-2021年6月广州医科大学附属第四医院收治的96例不明原因RSA患者。按照随机数字表法将其分为观察组和对照组,各48例。对照组给予常规治疗,观察组在对照组治疗的基础上给予淋巴细胞主动免疫治疗。比较两组临床疗效,治疗前后Th1/Th2/Th17细胞平衡状态、趋化因子CXC配体2(CXCL2)、趋化因子配体2(CCL2)蛋白表达水平、免疫指标及流产率。结果:观察组治疗总有效率显著高于对照组(P<0.05)。与治疗前相比,两组治疗后血清中干扰素-γ(interferon-γ,IFN-γ)、白介素-17(interleukin-17,IL-17)水平均显著下降,而白介素-10(interleukin-10,IL-10)水平显著上升(P<0.05);治疗后,观察组IFN-γ、IL-17水平均显著低于对照组,而IL-10水平显著高于对照组(P<0.05)。治疗后,观察组CXCL2、CCL2蛋白表达水平均显著高于对照组(P<0.05)。治疗后,两组CD3^(+)显著高于治疗前,CD19^(+)、CD4^(+)、Ig G、Ig M均显著低于治疗前(P<0.05);两组治疗前后Ig A比较差异无统计学意义(P>0.05);治疗后,观察组CD3^(+)显著高于对照组,CD19^(+)、CD4^(+)、Ig G、Ig M均显著低于对照组(P<0.05)。观察组流产率显著低于对照组(χ^(2)=14.892,P=0.000)。结论:淋巴细胞主动免疫在不明原因RSA患者中的治疗效果显著,能够改善患者外周血Th1/Th2/Th17细胞平衡与血清CXCL2、CCL2表达水平,降低流产率,具有较高的临床应用价值。Objective:To investigate the effect of lymphocyte active immunity treatment on patients with unexplained recurrent spontaneous abortion(RSA).Method:From July 2019 to June 2021,96 patients with unexplained RSA admitted to the Fourth Affiliated Hospital of Guangzhou Medical University were selected.According to the random number table method,they were divided into observation group and control group,48 cases in each group.The control group was given routine treatment,and the observation group was given lymphocyte active immunity treatment on the basis of the treatment of the control group.The clinical efficacy,Th1/Th2/Th17cells balance state,chemokine CXC ligand 2(CXCL2),chemokine ligand 2(CCL2)protein expression levels,immune indexes before and after treatment and abortion rate were compared between the two groups.Result:The treatment total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Compared with before treatment,the levels of interferon-γ(IFN-γ),interleukin-17(IL-17)were significantly decreased,while the level of interleukin-10(IL-10)was significantly increased in the two groups after treatment(P<0.05).After treatment,the levels of IFN-γand IL-17 in the observation group were significantly lower than those in the control group,while the level of IL-10 was significantly higher than that in the control group(P<0.05).After treatment,the protein expression levels of CXCL2 and CCL2 in the observation group were significantly higher than those in the control group(P<0.05).After treatment,CD3^(+)in the two groups was significantly higher than that before treatment,CD19^(+),CD4^(+),IgG,IgM were significantly lower than those before treatment(P<0.05).There was no significant difference in IgA between the two groups before and after treatment(P>0.05).After treatment,the CD3^(+)in the observation group was significantly higher than that in the control group,and the CD19^(+),CD4^(+),IgG and IgM in the observation group were significantly lower than those in the

关 键 词：淋巴细胞主动免疫 不明原因复发性流产 Th1/Th2/Th17细胞 趋化因子CXC配体2 趋化因子配体2 影响 疗效 

分 类 号：R714.21[医药卫生—妇产科学]