布地奈德福莫特罗联合噻托溴铵对老年COPD稳定期患者下呼吸道细菌定植、炎症因子、免疫功能及活动耐力的影响  

Effects of Budesonide Formoterol Combined with Tiotropium Bromide on Lower Airway Bacterial Colonization,Inflammatory Factors,Immune Function and Activity Tolerance in Elderly Patients with Stable Phase COPD

作　　者：陈华海 CHEN Huahai(Quanzhou Guangqian Hospital,Quanzhou 362000,China)

机构地区：[1]泉州市光前医院,福建泉州362000

出　　处：《中外医学研究》2023年第1期61-65,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析布地奈德福莫特罗联合噻托溴铵对老年慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者下呼吸道细菌定植(LABC)、炎症因子、免疫功能及活动耐力的影响。方法:选取2020年5月-2021年5月于泉州市光前医院就诊的老年COPD稳定期患者150例作为研究对象。随机将其分为对照组(75例)和试验组(75例)。两组均给予基础治疗,对照组给予噻托溴铵粉吸入剂,试验组在对照组基础上给予布地奈德福莫特罗吸入粉雾剂。比较两组治疗前及治疗3个月后肺功能、下呼吸道细菌定植阳性率、炎症因子、免疫功能、活动耐力及不良反应。结果:治疗3个月后,试验组第1秒用力呼气容积(FEV_(1))占预计值百分比(FEV_(1)%pred)、FEV_(1)、一秒率(FEV_(1)/FVC)均高于对照组(P<0.05)。治疗3个月后,试验组LABC阳性率低于对照组(χ^(2)=4.391,P=0.036)。治疗3个月后,试验组白三烯B_(4)(LTB_(4))、白细胞介素-8(IL-8)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平均低于对照组(P<0.05)。治疗3个月后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)与治疗前比较差异均无统计学意义(P>0.05),治疗前及治疗3个月后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)比较差异均无统计学意义(P>0.05)。治疗3个月后,两组6 min步行试验(6MWT)距离较治疗前延长(P<0.05),试验组6MWT距离长于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(χ^(2)=0.758,P=0.384)。结论:噻托溴铵联合布地奈德福莫特罗能抑制老年COPD稳定期患者炎症因子,降低LABC阳性率,改善患者肺功能,提升活动耐力。Objective:To analyze the effects of Budesonide Formoterol combined with Tiotropium Bromide on lower airway bacterial colonization(LABC)inflammatory factors,immune function and activity tolerance in elderly patients with stable phase chronic obstructive pulmonary disease(COPD).Method:A total of 150 elderly patients with stable phase COPD who were hospitalized in Quanzhou Guangqian Hospital from May 2020 to May 2021 were selected as research objects.They were randomly divided into control group(75 cases)and test group(75 cases).Both groups were given basic treatment,the control group was given Tiotropium Bromide Powder Inhalation,and the test group was given Budesonide Formoterol in haled powder spray on the basis of the control group.The pulmonary function,positive rate of LABC,inflammatory factors,immune function,activity tolerance before and after 3 months of treatment and adverse reactions were compared between the two groups.Result:After 3 months of treatment,the percentage of forced expiratory volume in one second(FEV_(1))in the predicted value(FEV_(1)%pred),FEV_(1),and one second rate(FEV_(1)/FVC)in the test group were higher than those in the control group(P<0.05).After 3 months of treatment,the positive rate of LABC in the test group was lower than that in the control group(χ^(2)=4.391,P=0.036).After 3 months of treatment,the levels of leukotriene B_(4)(LTB_(4)),interleukin-8(IL-8),high-sensitivity C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)in the test group were lower than those in the control group(P<0.05).After 3 months of treatment,there were no significant differences in CD3^(+),CD4^(+),CD4^(+)/CD8^(+)between the two groups compared with those before treatment(P>0.05).Before and after 3 months of treatment,there were no significant differences in CD3^(+),CD4^(+),CD4^(+)/CD8^(+)between the two groups(P>0.05).After 3 months of treatment,the 6 min walk test(6MWT)distance of the two groups was longer than that before treatment(P<0.05),and the 6MWT distance of the test group was longer

关 键 词：噻托溴铵 慢性阻塞性肺疾病 炎症 下呼吸道细菌定植 布地奈德福莫特罗 

分 类 号：R563.9[医药卫生—呼吸系统]