中医药治疗子宫内膜异位症的相关通路研究进展  

Pathways Involved in Treatment of Endometriosis with Chinese Medicines:A Review

作　　者：范伟森 刘姣[2] 张英杰[1] 王丹丹[1] 齐英华[3] FAN Weisen;LIU Jiao;ZHANG Yingjie;WANG Dandan;QI Yinghua(Shandong University of Traditional Chinese Medicine(TCM),Jinan 250014,China;Hebei University of Chinese Medicine,Shijiazhuang 050200,China;Affiliated Hospital of Shandong University of TCM,Jinan 250014,China)

机构地区：[1]山东中医药大学,济南250014 [2]河北中医学院,石家庄050200 [3]山东中医药大学附属医院,济南250014

出　　处：《中国实验方剂学杂志》2023年第3期233-243,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金青年基金项目(81803822);山东省博士后基金创新项目(202103016);山东省中医药科技项目(2020Q005)。

摘　　要：随着现代学者对于中医药干预子宫内膜异位症(EMS)研究的深入,从分子层面上发现了许多可以通过中药调控的EMS的相关通路。无论是中药复方、单味中药还是中药活性成分在干预EMS的机制研究中均与文中所论述的信号通路有着密切的关系。中药复方、单味中药和中药活性成分可以通过直接或间接的调控相应的信号通路中关键分子表达、抑制内膜异位细胞的增殖和组织炎性改变,促进内膜异位细胞的凋亡,改变疼痛阈值,减少内膜细胞侵袭,来达到抑制内膜异位组织进展、改善内膜容受性和减少卵巢损伤的治疗作用。现通过国内外的相关研究进行总结:莪术醇等可通过阻断Janus激酶2/信号转导和转录激活因子3(JAK2/STAT3)信号通路,促进细胞凋亡并抑制血管生成;淫羊藿苷等可通过阻断核转录因子-κB(NF-κB)信号通路,从而减轻炎症、促进细胞凋亡;葛根素等可通过抑制丝裂原活化蛋白激酶(MAPK)信号通路,抑制细胞增殖,促进细胞凋亡。柚皮素可激活MAPK信号通路,促进细胞凋亡;白茅苷等可通过抑制磷脂酰肌醇-3激酶/蛋白激酶B(PI3K/Akt)信号通路,抑制细胞增殖,促进细胞凋亡;白藜芦醇等可通过阻断转化生长因子-β(TGF-β)信号通路,抑制细胞增殖、减轻纤维化与粘连;丹皮酚等可通过阻断缺氧诱导因子-1(HIF-1)信号通路,抑制血管生成;葛根素等能够通过阻断雌激素信号通路,抑制细胞增殖,减少细胞侵袭。以上总结旨在为今后临床中医药治疗或实验研究EMS提供参考借鉴。The in-depth study of the intervention of endometriosis(EMS)with Chinese medicines has revealed many pathways that can be regulated by Chinese medicines in the treatment of EMS.Chinese medicinal compound prescriptions,single Chinese herbal medicines,or their active ingredients treat EMS via the signaling pathways discussed in this paper.They can directly or indirectly regulate the expression of key molecules in the corresponding signaling pathways to inhibit the proliferation of endometriotic cells and the inflammatory changes of endometrial tissue,promote the apoptosis of endometriotic cells,change the pain threshold,and reduce endometriotic cell invasion,so as to achieve the therapeutic effects of inhibiting EMS progression,improving endometrial receptivity,and reducing ovarian injury.The following details are based on relevant studies conducted both at home and abroad.Curcumol can inhibit angiogenesis and promote cell apoptosis by blocking the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.Icariin can reduce inflammation and promote cell apoptosis by blocking the nuclear factor-kappa B signaling pathway.Puerarin can suppress cell proliferation and promote cell apoptosis by inhibiting the mitogen-activated protein kinase(MAPK)signaling pathway and blocking the estrogen signaling pathway.Naringenin has the ability to activate the MAPK signaling pathway to promote cell apoptosis.Imperatorin can inhibit cell proliferation and promote cell apoptosis by inhibiting the phosphatidylinositol 3-kinase/protein kinase B signaling pathway.Resveratrol can inhibit cell proliferation and alleviate fibrosis and adhesion by blocking the transforming growth factor-beta signaling pathway.Paeonol can inhibit angiogenesis by blocking the hypoxia-inducible factor 1 signaling pathway.The above summary can serve as a reference for the future clinical treatment or experimental research of EMS with Chinese medicines.

关 键 词：中医药 子宫内膜异位症 通路 研究进展 

分 类 号：R2-0[医药卫生—中医学] R33[文化科学—情报学] G353.11R711.71