基于数据挖掘探讨金水相生法治疗肺肾气虚型COPD的用药规律  

Medication rules of mutual generation between metal and water in the treatment of chronic obstructive pulmonary disease of lung and kidney Qi deficiency syndrome based on data mining

作　　者：赵榕 汪奎 王娟[1] 谢鑫 牛彩琴[2] ZHAO Rong;WANG Kui;WANG Juan;XIE Xin;NIU Cai-qin(North Sichuan Medical College,Nanchong 637000,Sichuan,CHINA;Department of Traditional Chinese Medicine,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,CHINA)

机构地区：[1]川北医学院,四川南充637000 [2]川北医学院附属医院中医科,四川南充637000

出　　处：《海南医学》2023年第2期248-253,共6页Hainan Medical Journal

基　　金：川北医学院附院科研发展计划项目(编号:2021ZD010)。

摘　　要：目的挖掘肺肾气虚型慢性阻塞性肺疾病(COPD)的组方规律,为临床遣方用药及新药研发提供一定的理论依据。方法以中国知识资源总库(CNKI)中2000—2020年有关中医药治疗肺肾气虚型COPD的文献为主要数据来源,借助中医传承计算平台(V3.0)进行频次统计、关联规则分析、熵聚类分析等。结果根据纳排标准筛选出274篇临床文献,收录方剂共211首。使用高频次药物为黄芪、熟地黄、党参、五味子、茯苓等。用药功效主要以补虚药、化痰止咳平喘药、利水渗湿药和活血化瘀药为主。药物性味以温平、甘苦辛较为集中;归经主要归肺、脾、肾经。常用药对有黄芪-熟地黄、五味子-黄芪、茯苓-黄芪、党参-黄芪等。经关联规则与熵聚类数据分析,得出潜在新方4首。结论肺肾气虚型COPD患者,中医药治疗以补肺益肾、纳气平喘为主,兼化痰健脾、活血化瘀;核心组合和新方具有重要的临床指导意义,值得临床推广。Objective To explore the medication rules for chronic obstructive pulmonary disease(COPD)of lung and kidney Qi deficiency syndrome,so as to provide a certain theoretical basis for clinical prescription and new drug research and development.Methods The data were mainly from the clinical research using traditional Chinese medicine(TCM)in the treatment of COPD of lung and kidney Qi deficiency syndrome in the China National Knowledge Internet(CNKI)from 2000 to 2020.With the help of Traditional Chinese Medicine Inheritance Platform(V3.0),frequency statistics,association rule analysis and systematic clustering were performed.Results Based on the inclusion and exclusion criteria,274 clinical articles were selected and 211 prescriptions were included.The high-frequency drugs used were mainly Astragalus membranaceus,Rehmannia glutinosa,Codonopsis pilosula,Schisandra chinensis,and Poria cocos.According to the classification of pharmacological effect,the drugs for tonifying deficiency,dispelling phlegm,relieving cough and preventing asthma,clearing damp and promoting diuresis,as well as promoting blood circulation and removing blood stasis were concentrated.The drugs were mostly mild in nature and sweet,bitter and pungent in taste.The meridian tropism of the drugs was mainly concentrated in the meridians of the lung,spleen and kidney.Commonly used drug combinations included Astragalus membranaceus-Rehmannia glutinosa,Schisandra chinensis-Astragalus membranaceus,Poria cocos-Astragalus membranaceus,Codonopsis pilosula-Astragalus membranaceus.The analysis of association rules and entropy clustering data showed that 4 potential new prescriptions were obtained.Conclusion For patients with COPD of lung and kidney Qi deficiency syndrome,TCM treatment mainly focuses on tonifying the lung and kidney as well as receiving Qi and relieving asthma,followed by resolving phlegm and strengthening spleen,promoting blood circulation and removing blood stasis.The core combinations and new prescriptions have important clinical guiding signific

关 键 词：慢性阻塞性肺疾病 肺肾气虚型 金水相生法 中医药 数据挖掘 用药规律 

分 类 号：R563[医药卫生—呼吸系统]