交感神经及其神经递质调控间充质干细胞的研究进展  

Research progress of mesenchymal stem cells regulated by sympathetic nerve and its neurotransmitters

作　　者：陈美雄[1] 郑凯 徐明奎 袁仕国[1] CHEN Mei-xiong;ZHENG Kai;XU Ming-kui;YUAN Shi-guo(Derpartment of Orthopedics and Traumatology,Hainan Traditional Chinese Medicine Hospital,Haikou 570203,Hainan,CHINA;School of Basic Medical Sciences,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,CHINA)

机构地区：[1]海南省中医院骨伤科,海南海口570203 [2]右江民族医学院基础医学院,广西百色533000

出　　处：《海南医学》2023年第2期291-294,共4页Hainan Medical Journal

基　　金：海南省自然科学基金(编号:822MS183);海南省临床医学中心建设项目资助(编号:琼卫医函[2021]276号)。

摘　　要：间充质干细胞(MSCs)属于成体干细胞,主要存在于结缔组织和器官间质中,是组织损伤修复、衰老改变等的关键。近来研究发现交感神经及其神经递质对MSCs的动员、归巢、增殖、分化,以及干细胞巢、微环境等存在多位点、多阶段的影响和调控。本文拟总结交感神经及其神经递质介导、调控MSCs的相关研究,为MSCs的进一步研究、应用等提供参考和思路。Mesenchymal stem cells(MSCs)are adult stem cells,which mainly exist in connective tissue and organ stroma.They are the key to tissue damage repair and aging changes.Recent studies have found that sympathetic nerve and its neurotransmitters have multi-point and multi-stage effects and regulation on the mobilization,homing,proliferation,and differentiation of MSCs,as well as stem cell niche and microenvironment.This paper intends to summarize the related research of sympathetic nerve and its neurotransmitter-mediated and regulated MSCs,so as to provide reference and ideas for the further research and application of MSCs.

关 键 词：自主神经系统 交感神经受体 间充质干细胞 微环境 去甲肾上腺素 

分 类 号：R338[医药卫生—人体生理学]