唑来膦酸联合经皮球囊椎体成形术在骨质疏松椎体压缩性骨折治疗中的效果  

Effectiveness of Zoledronic Acid Combined with Percutaneous Balloon Vertebroplasty in the Treatment of Osteoporotic Vertebral Compression Fractures

作　　者：张鹏 李传明 杨晓峰[1] ZHANG Peng;LI Chuanming;YANG Xiaofeng(Department of Orthopedics,Xuzhou Cancer Hospital,Xuzhou,Jiangsu Province,221005 China)

机构地区：[1]徐州市肿瘤医院骨科,江苏徐州221005

出　　处：《系统医学》2022年第20期74-77,86,共5页Systems Medicine

摘　　要：目的探究唑来膦酸联合经皮球囊椎体成形术在骨质疏松椎体压缩性骨折治疗中应用价值。方法选取徐州市肿瘤医院2019年10月—2021年9月期间收治的92例骨质疏松椎体压缩性骨折患者,以随机数表法分为对照组和观察组,各46例,对照组实施经皮球囊椎体成形术治疗,观察组实施经皮球囊椎体成形术联合唑来膦酸治疗,均随访至术后3个月,比较两组患者不同时间(术后1、3个月)疼痛感受(VAS)、Oswestry功能障碍指数(ODI)、椎体前缘/后缘高度比、Cobb角及再次骨折发生率。结果术后1、3个月,观察组VAS评分(3.07±0.58)分、(1.81±0.42)分低于对照组(3.74±0.61)分、(2.52±0.41)分,ODI指数(25.39±3.18)分、(20.48±1.25)分低于对照组(29.28±3.30)分、(24.31±2.09)分,差异有统计学意义(t=5.399、8.204、5.757、10.667,P<0.05);术后1、3个月,观察组椎体前缘/后缘高度比大于对照组,Cobb角小于对照组,差异有统计学意义(t=5.668、5.705、4.898、7.942,P<0.05);观察组再次骨折发生率为2.17%(1/46),低于对照组的17.39%(8/46),差异有统计学意义(χ^(2)=4.434,P<0.05)。结论在对骨质疏松椎体压缩性骨折患者治疗中,应用经皮球囊椎体成形术联合唑来膦酸治疗,可缓解患者术后疼痛感受,改善其腰椎功能、提升椎体前/后缘高度、降低Cobb角水平,并减少再次骨折发生率。Objective To investigate the value of zoledronic acid combined with percutaneous balloon vertebroplasty in the treatment of osteoporotic vertebral compression fractures.Methods 92 patients with osteoporotic vertebral compression fractures admitted to Xuzhou Cancer Hospital from October 2019 to September 2021 were selected and divided into control group and observation group by random number table method,46 cases in each group.The control group was treated with percutaneous balloon vertebroplasty,and the observation group was treated with percutaneous balloon vertebroplasty combined with zoledronic acid.Both groups were followed up until 3 months after surgery,and the incidence of pain perception(VAS),Oswestry dysfunction index(ODI),anterior/posterior vertebral body height ratio,Cobb angle and re-fracture were compared between the two groups at different times(1 month and 3 months after surgery).Results At 1 month and 3 months after surgery,the VAS scores of the observation group(3.07±0.58)points and(1.81±0.42)points were lower than those of the control group(3.74±0.61)points and(2.52±0.41)points,the ODI index(25.39±3.18)points and(20.48±1.25)points were lower than those of the control group(29.28±3.30)points and(24.31±2.09)points,the differences was statistically significant(t=5.399,8.204,5.757,10.667,P<0.05).The height ratio of the anterior/posterior edge of the vertebral body in the observation group was greater than that in the control group at 1 month and 3 months after surgery,and the Cobb angle was smaller than that in the control group,the differences was statistically significant(t=5.668,5.705,4.898,7.942,P<0.05).The incidence of re-fracture in the observation group was 2.17%(1/46),which was lower than that in the control group 17.39%(8/46),and the difference was statistically significant(χ^(2)=4.434,P<0.05).Conclusion In the treatment of patients with osteoporotic vertebral compression fractures,the application of percutaneous balloon vertebroplasty combined with zoledronic acid therapy can reli

关 键 词：骨质疏松 椎体压缩性骨折 经皮球囊椎体成形术 唑来膦酸 椎体前缘/后缘高度比 

分 类 号：R687[医药卫生—骨科学]