左归丸联合骨化三醇治疗骨质疏松性股骨粗隆间骨折术后肾虚精亏型患者的临床观察  

Effect of Zuogui Pills plus Calcitriol on Osteoporotic Intertrochanteric Fracture of Femur(Syndrome of Kidney and Essence Deficiency)after Operation

作　　者：董涛 曹军华 DONG Tao;CAO Jun-hua(Beijing Hospital of Integrated Chinese Traditional and Western Medicine,Beijing 100039;Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang Hubei 441021)

机构地区：[1]北京中西医结合医院,北京100039 [2]湖北文理学院附属医院,襄阳市中心医院,湖北襄阳441021

出　　处：《世界中西医结合杂志》2022年第11期2227-2231,共5页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察采用股骨近端防旋髓内钉术后联合左归丸和骨化三醇治疗骨质疏松性股骨粗隆间骨折的临床疗效。方法选取2015年5月—2017年5月期间北京中西医结合医院骨科收治的伴有骨质疏松的股骨粗隆骨折患者110例,根据入院顺序分为对照组和治疗组,每组各55例。术后两组患者均口服骨化三醇软胶囊,治疗组患者使用左归丸。治疗6个月后,观察比较两组患者临床疗效、疼痛程度、不良反应情况及治疗前后血清骨钙素(Bone-γ-Carboxyglutamic Acid-Containing protein,BGP)、骨碱性磷酸酶(Bone Alkaline Phosphatase,BALP)、钙离子(Ca^(2+))水平和中医症状评分。结果治疗6个月后治疗组总有效率81.82%(45/55)与对照组43.64%(24/55)比较,差异有统计学意义(P<0.05)。治疗后治疗组疼痛程度较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者BGP、BALP水平均较治疗前明显升高,差异有统计学意义(P<0.05);且治疗组BGP、BALP水平均较对照组明显升高,差异有统计学意义(P<0.05)。治疗后治疗组Ca^(2+)水平较治疗前降低,差异有统计学意义(P<0.05);且治疗组优于对照组,差异有统计学意义(P<0.05)。治疗6个月后两组患者中医证候评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组中医证候评分明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论股骨近端防旋髓内钉术治疗骨质疏松性股骨粗隆间骨折疗效确切,联合左归丸和骨化三醇软胶囊,可增强疗效,提高骨折愈合质量,降低再骨折风险。Objective To observe the clinical effect of Zuogui pills plus calcitriol on osteoporotic intertrochanteric fracture of femur after proximal femoral nail antirotation(PFNA).Methods A total of 110 patients with osteoporotic intertrochanteric fracture of femur treated with PFNA in the Beijing Hospital of Integrated Chinese Traditional and Western Medicine from May 2015 to May 2017 were included in this study and assigned into a control group(n=55)and an observation group(n=55)according to the order of admission.Calcitriol soft capsules were administrated in both groups after operation,and the patients in the observation group were additionally treated with Zuogui pills.Six months after operation,the clinical efficacy and pain degree were compared between the two groups.The TCM syndrome score and the serum levels of boneγ-carboxyglutamic acid-containing protein(BGP),bone alkaline phosphatase(BALP),and Ca^(2+)were compared between before and after operation as well as between the two groups.The adverse reactions were recorded during the treatment period.Results After six months of treatment,the clinical efficacy of the observation group was 81.82%(45/55),which was higher than that(43.64%,24/55)of the control group(P<0.05),and the observation group had lower pain degree than the control group(P<0.05).The treatment in both groups elevated the serum levels of BGP and BALP and lowered the Ca^(2+)level,which were more obvious in the observation group(P<0.05).The TCM syndrome score declined in both groups after six months of treatment(P<0.05)and was lower in the observation group than in the control group(P<0.05).During the treatment period,the incidence of adverse reactions showed no significant difference between the two groups(P>0.05).Conclusion PFNA is effective for the treatment of osteoporotic intertrochanteric fracture of femur.Zuogui pills plus calcitriol soft capsules can improve the healing quality and reduce the risk of re-fracture.

关 键 词：股骨粗隆间骨折 左归丸 骨化三醇 骨质疏松 

分 类 号：R274.1[医药卫生—中医骨伤科学]