脾氨肽口服冻干粉、天灸联合小儿健脾补肺膏治疗小儿反复呼吸道感染肺脾气虚证临床观察  

Clinical efficacy of spleen aminopeptide oral lyophilized powder,crude herb moxibustion combined with Xiaoer Jianpi Bufei Ointment for recurrent respiratory tract infection of lung-spleen qi deficiency syndrome

作　　者：莫珊 姜美琳 董文迪 蔡靖宜 潘靖波 邬素珍 MO Shan;JIANG Meilin;DONG Wendi;CAI Jingyi;PAN Jingbo;WU Suzhen(Department of Traditional Chinese Medicine,Foshan Fosun Chancheng Hospital,Foshan,Guangdong 528000;Foshan College of Clinical Medicine,Guangzhou University of Chinese Medicine,Foshan,Guangdong 528000;Department of Traditional Chinese Medicine and Gynecology,Foshan Fosun Chancheng Hospital,Foshan,Guangdong 528000)

机构地区：[1]佛山复星禅诚医院中医科,广东佛山528000 [2]广州中医药大学佛山临床医学院,广东佛山528000 [3]佛山复星禅诚医院中医妇科,广东佛山528000

出　　处：《河北中医》2022年第12期1999-2004,共6页Hebei Journal of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20201342);佛山市科学技术局科技创新项目(编号:1920001001021)。

摘　　要：目的观察脾氨肽口服冻干粉、天灸联合小儿健脾补肺膏治疗小儿反复呼吸道感染肺脾气虚证的临床疗效。方法将181例反复呼吸道感染肺脾气虚证患儿按照随机数字表法分为4组,对照组45例予脾氨肽口服冻干粉治疗,天灸组45例予天灸治疗,小儿健脾补肺膏组45例予小儿健脾补肺膏治疗,联合组46例予脾氨肽口服冻干粉、天灸联合小儿健脾补肺膏治疗。比较4组疗效及中医疗效;观察4组治疗前后中医症状评分变化;观察4组治疗前后免疫功能指标变化。结果治疗过程中对照组1例、天灸组1例、联合组1例中途退出。对照组总有效率63.64%(28/44),天灸组总有效率75.00%(33/44),小儿健脾补肺膏组总有效率75.56%(34/45),联合组总有效率93.33%(42/45),联合组疗效优于对照组、天灸组、小儿健脾补肺膏组(P<0.05),对照组、天灸组、小儿健脾补肺膏组总有效率比较差异均无统计学意义(P>0.05),3组疗效相当。对照组总有效率68.18%(30/44),天灸组总有效率79.55%(35/44),小儿健脾补肺膏组总有效率80.00%(36/45),联合组总有效率95.56%(43/45),联合组中医疗效优于对照组、天灸组、小儿健脾补肺膏组(P<0.05),对照组、天灸组、小儿健脾补肺膏组总有效率比较差异均无统计学意义(P>0.05),3组中医疗效相当。4组治疗后中医症状评分均低于本组治疗前(P<0.05),治疗后天灸组、小儿健脾补肺膏组、联合组中医症状评分均低于对照组(P<0.05),治疗后联合组中医症状评分低于天灸组、小儿健脾补肺膏组(P<0.05),治疗后天灸组中医症状评分与小儿健脾补肺膏组比较差异无统计学意义(P>0.05)。4组治疗后血清免疫球蛋白G(IgG)、IgA、IgM水平及CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于本组治疗前(P<0.05),CD8^(+)水平均低于本组治疗前(P<0.05);治疗后天灸组、小儿健脾补肺膏组、联合组血清IgG、IgA、IgM水平及CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水�Objective To observe the clinical efficacy of spleen aminopeptide oral lyophilized powder(SAOLP),crude herb moxibustion combined with Xiaoer Jianpi Bufei Ointment for recurrent respiratory tract infection(RRTI)of lung-spleen qi deficiency syndrome(LSQDS).Methods Totally 181 children with RRTI of LSQDS were randomly assigned to SAOLP group(n=45,slough off 1 case),crude herb moxibustion(CHM)group(n=45,slough off 1 case),Xiaoer Jianpi Bufei Ointment(XJBO)group(n=45),or combined group(n=46).The aim was to compare the curative effect,the curative effect of traditional Chinese medicine(TCM),TCM symptom score,immune function index before and after treatment.Results The overall effective rate and curative effect in SAOLP group,the CHM group,XJBO group,the combined group was(63.64%[28/44],75.00%[33/44],75.56%[34/45],93.33%[42/45],respectively);(68.18%[30/44],79.55%[35/44],80.00%[36/45],95.56%[43/45],respectively);which in the combined group was superior to others(all P<0.05),but no difference was statistically significant among the other threes(all P>0.05).After treatment,TCM symptom scores in groups were decreased(P<0.05);TCM symptom scores in three TCM group were decreased relative to SAOLP group(P<0.05),which were the lowest in the combined group among the three TCM group(P<0.05);but no difference was statistically significant between the CHM group and XJBO group(P>0.05).After treatment,increased immunoglobulin G(IgG),IgA,IgM,CD3^(+),CD4^(+),CD4^(+)/CD8^(+),and decreased CD8^(+)were found in groups(P<0.05),the three TCM groups were superior to SAOLP group for the above indexes(all P<0.05),which were more prevalent in the combination group with respect to CHM group and XJBO group(all P<0.05),and the difference was not statistically significant between CHM group and XJBO group(P>0.05).Conclusion For children with RRTI of LSQDS,the combination therapy can alleviate clinical symptoms,improve immune function,and improve clinical efficacy.

关 键 词：呼吸道感染 外治疗法 穴位贴敷疗法 

分 类 号：R373.1[医药卫生—病原生物学] R244[医药卫生—基础医学]