蛋白质组学在溃疡性结肠炎研究中的应用与进展  

Application and Progress of Proteomics on Ulcerative Colitis Research

作　　者：项楠 丰依明 孔维崧 周桂 周昕[1] XIANG Nan;FENG Yiming;KONG Weisong;ZHOU Gui;ZHOU Xin(Department of Pharmacy,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院药学部,上海200032

出　　处：《中国现代应用药学》2022年第23期3176-3182,共7页Chinese Journal of Modern Applied Pharmacy

摘　　要：溃疡性结肠炎的发病率日渐上升,其发病机制目前尚不清楚,临床上也暂无得到广泛认可的生物标志物。蛋白质组学技术在寻找生物标志物方面有很大的优势,发现了许多潜在标志物如CPS1、TRAP1、MMP10、CXCL9、CCL11、S100A8/9、TRANCE和OSM等。这些标志物经过更多验证后有望在临床进行推广,可应用于如通过不同标志物进行无创诊断、病程预测等情况,这也是未来临床发展的新趋势。本文对近年来使用该技术在溃疡性结肠炎的发病机制、与克罗恩病的区分以及监测疾病进展情况等方面找到的生物标志物进行了概述。The incidence of ulcerative colitis has been increasing recently but its pathogenesis is still unclear,and there are none well-acknowledged biomarkers in the clinical practice.Proteomics has great advantages when serving as tools for biomarker discoveries.Many potential biomarkers such as CPS1,TRAP1,MMP10,CXCL9,CCL11,S100A8/9,TRANCE and OSM were identified.These biomarkers are expected to be promoted in the clinic after more validation and can be applied in situations such as non-invasive diagnosis and disease course prediction by different biomarkers,which is a new trend for future clinical development.This review provides an overview of the biomarkers found in recent years using this technique in the pathogenesis of ulcerative colitis,differentiation from Crohn’s disease,and monitoring of ulcerative colitis disease progression.

关 键 词：溃疡性结肠炎 蛋白质组学 生物标志物 

分 类 号：R969.3[医药卫生—药理学]