阿利沙坦与坎地沙坦治疗轻-中度原发性高血压的效果和安全性比较  

Comparison of efficacy and safety between alisartan and candesartan in mild to moderate primary hypertension

作　　者：陈安[1] 潘敏[1] 翟永新[2] 白建雄[2] 梁国泉 CHEN An;PAN Min;ZHAI Yong-xin(Department of Clinical pharmacy,Zhaoqing Second People's Hospital,Zhaoqing 526060,China)

机构地区：[1]肇庆市第二人民医院临床药学科,广东肇庆526060 [2]肇庆市第二人民医院心血管内科,广东肇庆526060

出　　处：《中国处方药》2023年第1期20-25,共6页Journal of China Prescription Drug

基　　金：肇庆市科技创新指导类项目(202004031424)。

摘　　要：目的探讨阿利沙坦和坎地沙坦治疗轻-中度原发性高血压的效果和安全性。方法选取2020年5月~2021年2月的肇庆市第二人民医院心血管内科就诊的212例轻-中度原发性高血压患者作为研究对象,采用随机交替分组法,经2周导入期后,将入组160例患者分为观察组80例和对照组80例,分别予阿利沙坦酯片、坎地沙坦酯片治疗8周。观察两组患者的血压变化情况、达标率和有效率以及安全性指标。结果疗效结果显示,两组患者的收缩压(SBP)和舒张压(DBP)均低于基线水平,差异有统计学意义(P<0.05);治疗2周、4周、6周后,观察组的SBP和DBP均低于对照组,差异有统计学意义(P<0.05)。治疗8周后,观察组的SBP仍低于对照组,差异有统计学意义(P=0.01);两组DBP下降值比较,差异无统计学意义(P=0.05)。两组治疗后白天(清醒活动)、夜间(睡眠)以及24 h的SBP、DBP值均低于基线水平,差异有统计学意义(P<0.05)。观察组的白天(清醒活动)、夜间(睡眠)以及24 h的SBP、DBP值均低于对照组,差异有统计学意义(P<0.05)。两组患者治疗4周、6周、8周后SBP和DBP的下降幅度,均高于治疗2周后的下降幅度,差异有统计学意义(P<0.05)。治疗后两组的白天、夜间、24 h的SBP以及白天DBP降幅比较,差异无统计学意义(P>0.05);但观察组的夜间和24 h DBP降幅高于对照组,差异有统计学意义(P<0.05)。治疗后两组降压疗效和达标率比较,差异无统计学意义(P>0.05)。发生不良反应共13例,其中观察组6例(7.5%),对照组7例(8.75%),差异无统计学意义(P=0.83)。结论阿利沙坦和坎地沙坦均能显著降低轻-中度原发性高血压患者的收缩压和舒张压,安全性良好。但阿利沙坦降压幅度更加明显,可作为轻-中度原发性高血压患者的优选治疗药物。Objective To investigate the clinical efficacy and safety of alisartan and candesartan in mild to moderate primary hypertension.Methods Selected 212 patients with mild to moderate essential hypertension in the Department of Cardiovascular Medicine,Zhaoqing Second People’s Hospital from May 2020 to February 2021 as the research objects.Randomized alternate grouping was used.After a 2-week lead-in period,Divided the 160 patients into the observation group of 80 cases and the control group of 80 cases,and the observation group were treated with allisartan medoxomil tablets and the control group were treated with candesartan medoxomil tablets for 8 weeks.Observe the changes in blood pressure,compliance rate and effective rate of the two groups of patients,as well as safety indicators.Results The efficacy results showed that the systolic blood pressure(SBP)and diastolic blood pressure(DBP)of the two groups were lower than the baseline level,and the difference was statistically significant(P<0.05);after 2 weeks,4 weeks,and 6 weeks of treatment,the observation group both SBP and DBP decreased more than those in the control group,and the difference was statistically significant(P<0.05).After 8 weeks of treatment,the decrease in SBP of the observation group was still more than that of the control group,and the difference was statistically significant(P=0.01);the difference in the decrease of DBP between the two groups was not statistically significant(P=0.05).The average values of SBP and DBP during the day(waking activity),night(sleeping)and 24 hours after treatment were lower than the baseline level,and the difference was statistically significant(P<0.05).The average values of SBP and DBP during the day(waking activity),night(sleep)and 24 hours of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).The decline in SBP and DBP after 4 weeks,6 weeks,and 8 weeks of treatment in the two groups was higher than the decline after 2 weeks of treatment,and th

关 键 词：阿利沙坦 坎地沙坦 轻-中度原发性高血压 疗效 安全性 

分 类 号：R544.11[医药卫生—心血管疾病]